An unusual case of loperamide anaphylaxis

Adrian Y.S. Lee; Anthony J.F. Smith; Matthew Krummenacher; Tiffany L. Hughes

doi:10.1016/j.anai.2019.10.017

An unusual case of loperamide anaphylaxis

Adrian Y.S. Lee, Anthony J.F. Smith, Matthew Krummenacher, Tiffany L. Hughes

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

A 75-year-old, nonatopic man had been experiencing a gastroenteritis-like illness for the last 24 hours characterized by diarrhea and malaise. He decided to take, for the first time, 4 mg of loperamide hydrochloride to assist with symptom relief. Within 30 minutes, he developed severe anaphylaxis with widespread urticaria, presyncope, and acute worsening of diarrhea and vomiting. He was transported by ambulance to the hospital, where his initial blood pressure was 82/50 mm Hg. He was successfully resuscitated with 2 doses of intramuscular epinephrine (1 mg total) and intravenous saline.

Original language	English
Pages (from-to)	93-94
Number of pages	2
Journal	Annals of Allergy, Asthma and Immunology
Volume	124
Issue number	1
DOIs	https://doi.org/10.1016/j.anai.2019.10.017
Publication status	Published - Jan 2020

Keywords

loperamide
anaphylaxis
Urticaria
presyncope
hypercholesterolemia
skin testing

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AB - A 75-year-old, nonatopic man had been experiencing a gastroenteritis-like illness for the last 24 hours characterized by diarrhea and malaise. He decided to take, for the first time, 4 mg of loperamide hydrochloride to assist with symptom relief. Within 30 minutes, he developed severe anaphylaxis with widespread urticaria, presyncope, and acute worsening of diarrhea and vomiting. He was transported by ambulance to the hospital, where his initial blood pressure was 82/50 mm Hg. He was successfully resuscitated with 2 doses of intramuscular epinephrine (1 mg total) and intravenous saline.

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KW - hypercholesterolemia

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An unusual case of loperamide anaphylaxis

Abstract

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