Analgesia from morphine and ketamine: A comparison of infusions of morphine and ketamine for postoperative analgesia

H. OWEN, R. M. REEKIE, J. A. CLEMENTS, R. WATSON, W. S. NIMMO

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Ketamine 4 μg/kg/minute produced pain relief similar to that from morphine 33 μg/minute in a doubleblind study that compared analgesia from constant‐rate intravenous infusions of the two drugs in 60 patients. The analgesic efficacy of the infusions, as assessed by pain scores and the requirement for supplementary self‐administered morphine, was poor. Ventilatory depression, the most significant side effect, occurred only in patients who received morphine infusion. The low dose ketamine infusion did not provide clinically useful analgesia even though adequate plasma concentrations were achieved.

Original languageEnglish
Pages (from-to)1051-1056
Number of pages6
JournalAnaesthesia
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 1987
Externally publishedYes

Keywords

  • Anaesthetics, intravenous; ketamine
  • Analgesics, narcotic; morphine

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