Analytical Evaluation of GeneXpert CT/NG, the First Genetic Pointof-Care Assay for Simultaneous Detection of Neisseria gonorrhoeae and Chlamydia trachomatis

Sepehr Tabrizi, Magnus Unemo, Daniel Golparian, Jimmy Twin, E Limnios, Monica Lahra, Rebecca Guy, James Ward, John Kaldor, Basil Donovan, David Wilson, Handan Wand, David Regan, Louise Causer, Belinda Hengel, Lisa Natoli, David Anderson, David Whiley, Mark Shephard, Christopher Fairley

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    46 Citations (Scopus)

    Abstract

    GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.

    Original languageEnglish
    Pages (from-to)1945-1947
    Number of pages3
    JournalJournal of Clinical Microbiology
    Volume51
    Issue number6
    DOIs
    Publication statusPublished - Jun 2013

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    Tabrizi, S., Unemo, M., Golparian, D., Twin, J., Limnios, E., Lahra, M., Guy, R., Ward, J., Kaldor, J., Donovan, B., Wilson, D., Wand, H., Regan, D., Causer, L., Hengel, B., Natoli, L., Anderson, D., Whiley, D., Shephard, M., & Fairley, C. (2013). Analytical Evaluation of GeneXpert CT/NG, the First Genetic Pointof-Care Assay for Simultaneous Detection of Neisseria gonorrhoeae and Chlamydia trachomatis. Journal of Clinical Microbiology, 51(6), 1945-1947. https://doi.org/10.1128/JCM.00806-13