Anatomical optical coherence tomography for long-term, portable, quantitative endoscopy

Matthew S. Leigh, Julian J. Armstrong, Alexandre Paduch, Jennifer H. Walsh, David R. Hillman, Peter R. Eastwood, David D. Sampson

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


In this paper, we report on anatomical optical coherence tomography, a catheter-based optical modality designed to provide quantitative sectional images of internal hollow organ anatomy over extended observational periods. We consider the design and performance of an instrument and its initial intended application in the human upper airway for the characterization of obstructive sleep apnea (OSA). Compared with current modalities, the technique uniquely combines quantitative imaging, bedside operation, and safety for use over extended periods of time with no cumulative dose limit. Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record dynamic changes in airway size and shape.

Original languageEnglish
Pages (from-to)1438-1446
Number of pages9
JournalIEEE Transactions On Biomedical Engineering
Issue number4
Publication statusPublished - Apr 2008
Externally publishedYes

Bibliographical note

Funding Information:
Manuscript received May 27, 2007; revised October 10, 2007. This work was supported in part by the Medical Research Foundation of Western Australia, the Australian Health Management Group, and more recently the National Health and Medical Research Council, Australia, under Development Grant 303319. The work of P. R. Eastwood was supported by the National Health and Medical Research Council, Australia, under R. Douglas Wright Fellowship 294404. Asterisk indicates corresponding author. *M. S. Leigh is with the Optical+Biomedical Engineering Laboratory (OBEL), School of Electrical, Electronic & Computer Engineering, University of Western Australia, 35 Stirling Highway, M018, Crawley, W.A. 6009, Australia (e-mail:

Copyright 2008 Elsevier B.V., All rights reserved.


  • Biomedical optical imaging
  • Endoscopy
  • Optical coherence tomography
  • Sleep apnea
  • Upper airway


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