Ancestry of the iban is predominantly Southeast Asian: Genetic evidence from autosomal, Mitochondrial, and Y Chromosomes

Tatum Simonson, Jingchuan Xing, Robert John Barrett, Edward Jerah, Peter Loa, Yuhua Zhang, William Watkins, David Witherspoon, Chad Huff, Scott Woodward, Bryan Mowry, Lynn Jorde

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    Abstract

    Humans reached present-day Island Southeast Asia (ISEA) in one of the first major human migrations out of Africa. Population movements in the millennia following this initial settlement are thought to have greatly influenced the genetic makeup of current inhabitants, yet the extent attributed to different events is not clear. Recent studies suggest that southto- north gene flow largely influenced present-day patterns of genetic variation in Southeast Asian populations and that late Pleistocene and early Holocene migrations from Southeast Asia are responsible for a substantial proportion of ISEA ancestry. Archaeological and linguistic evidence suggests that the ancestors of present-day inhabitants came mainly from north-tosouth migrations from Taiwan and throughout ISEA approximately 4,000 years ago. We report a large-scale genetic analysis of human variation in the Iban population from the Malaysian state of Sarawak in northwestern Borneo, located in the center of ISEA. Genome-wide single-nucleotide polymorphism (SNP) markers analyzed here suggest that the Iban exhibit greatest genetic similarity to Indonesian and mainland Southeast Asian populations. The most common non-recombining Y (NRY) and mitochondrial (mt) DNA haplogroups present in the Iban are associated with populations of Southeast Asia. We conclude that migrations from Southeast Asia made a large contribution to Iban ancestry, although evidence of potential gene flow from Taiwan is also seen in uniparentally inherited marker data.

    Original languageEnglish
    Article numbere16338
    Pages (from-to)e16338
    Number of pages8
    JournalPLoS One
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 2011

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    Simonson, T., Xing, J., Barrett, R. J., Jerah, E., Loa, P., Zhang, Y., Watkins, W., Witherspoon, D., Huff, C., Woodward, S., Mowry, B., & Jorde, L. (2011). Ancestry of the iban is predominantly Southeast Asian: Genetic evidence from autosomal, Mitochondrial, and Y Chromosomes. PLoS One, 6(1), e16338. [e16338]. https://doi.org/10.1371/journal.pone.0016338