Ancient human genomes reveal a hidden history of strong selection in Eurasia

Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane T Grey, Joshua Schmidt, João C Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia L Johnson, Graham Gower, Christopher Turney, Murray Cox, Christian D. Huber, Alan Cooper

Research output: Contribution to journalArticle

Abstract

The role of selection in shaping genetic diversity in natural populations is an area of intense interest in modern biology, especially the characterization of adaptive loci. Within humans, the rapid increase in genomic information has produced surprisingly few well-defined adaptive loci, promoting the view that recent human adaptation involved numerous loci with small fitness benefits. To examine this we searched for signatures of hard sweeps – the selective fixation of a new or initially rare beneficial variant – in 1,162 ancient western Eurasian genomes and identified 57 sweeps with high confidence. This unexpectedly extensive signal was concentrated on proteins acting at the cell surface, and potential selection pressures include cold adaptation in early Eurasian populations, and oxidative stress from carbohydrate-rich diets in farming populations. Critically, these sweep signals have been obscured in modern European genomes by subsequent
population admixture, especially during the Bronze Age (5-3kya) and empires of classical antiquity.
Original languageEnglish
JournalbioRxiv
DOIs
Publication statusE-pub ahead of print - 3 Apr 2020
Externally publishedYes

Keywords

  • Ancient DNA
  • aDNA
  • Adaptation
  • Admixture
  • Eurasia
  • Selection
  • Demography
  • Population Structure
  • Sweep
  • Allele Frequency

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