Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Louisa A. Ho, Colin L. Raston, Keith A. Stubbs

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A3-coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A3-coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.

    Original languageEnglish
    Pages (from-to)8869-8874
    Number of pages6
    JournalChemistry - A European Journal
    Volume24
    Issue number35
    DOIs
    Publication statusPublished - 21 Jun 2018

    Keywords

    • A coupling
    • multicomponent reactions
    • photocatalysis
    • thin-film microfluidics
    • vortex fluidics

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