Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Louisa A. Ho; Colin L. Raston; Keith A. Stubbs

doi:10.1002/chem.201801109

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Louisa A. Ho
, Colin L. Raston
, Keith A. Stubbs

Flinders Institute for Nanoscale Science and Technology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A³-coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A³-coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.

Original language	English
Pages (from-to)	8869-8874
Number of pages	6
Journal	Chemistry - A European Journal
Volume	24
Issue number	35
DOIs	https://doi.org/10.1002/chem.201801109
Publication status	Published - 21 Jun 2018

Keywords

A coupling
multicomponent reactions
photocatalysis
thin-film microfluidics
vortex fluidics

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AU - Raston, Colin L.

AU - Stubbs, Keith A.

PY - 2018/6/21

Y1 - 2018/6/21

N2 - The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A3-coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A3-coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.

AB - The dynamic thin film formed in an angled rapidly rotating tube in a vortex fluidic device (VFD) is effective in facilitating multicomponent reactions (MCRs) as photocatalytic or metal-mediated processes. Here, we demonstrate the utility of the VFD by using two known MCRs, an Ugi-type three component reaction and an A3-coupling reaction. The Ugi-type reaction can be done in either confined or continuous-flow modes of operation of the microfluidic platform whereas the A3-coupling reaction was optimized for the confined mode of operation. The examples tested gave excellent yields with short reaction times.

KW - A coupling

KW - multicomponent reactions

KW - photocatalysis

KW - thin-film microfluidics

KW - vortex fluidics

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UR - http://purl.org/au-research/grants/ARC/DP170100452

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DO - 10.1002/chem.201801109

M3 - Article

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 35

ER -

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

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Keywords

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