Animal cell division: A fellowship of the double ring?

Robert B. Saint, W. Gregory Somers

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Despite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has remained elusive. The discovery of a novel interaction between regulators of Rho family small GTPases has revealed a link between the mitotic microtubules and the contractile ring during the later stages of mitosis. The properties of the interacting Rho regulators suggest a molecular model for the positioning and initiation of contractile ring furrowing in animal cells. In this `double ring' model, centralspindlin complexes, localized by the action of their kinesin-like protein component, position and activate a cortical equatorial ring of Rho GTPase exchange factors. The resulting ring of activated Rho would then trigger a cascade of events leading to formation and constriction of the contractile ring.
Original languageEnglish
Pages (from-to)4277-4281
Number of pages5
JournalJournal of Cell Science
Issue number21
Publication statusPublished - 2003


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