Anorexia nervosa

Janet Treasure, Stephan Zipfel, Nadia Micali, Tracey Wade, Eric Stice, Angelica Claudino, Ulrike Schmidt, Guido Frank, Cynthia M Bulik, Elisabet Wentz

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. AN predominantly develops in adolescence in the peripubertal period. Without early effective treatment, the course is protracted with physical, psychological and social morbidity and high mortality. Despite these effects, patients are noted to value the beliefs and behaviours that contribute to their illness rather than regarding them as problematic, which interferes with screening, prevention and early intervention. Involving the family to support interventions early in the course of the illness can produce sustained changes; however, those with a severe and/or protracted illness might require inpatient nursing support and/or outpatient psychotherapy. Prevention programmes aim to moderate the overvaluation of 'thinness' and body dissatisfaction as one of the proximal risk factors. The low prevalence of AN limits the ability to identify risk factors and to study the timing and sex distribution of the condition. However, genetic profiles, premorbid features, and brain structures and functions of patients with AN show similarities with other psychiatric disorders and contrast with obesity and metabolic disorders. Such studies are informing approaches to address the neuroadaptation to starvation and the other various physical and psychosocial deficits associated with AN. This Primer describes the epidemiology, diagnosis, screening and prevention, aetiology, treatment and quality of life of patients with AN.

Original languageEnglish
Article number15074
Number of pages21
JournalNature reviews. Disease primers
Volume1
DOIs
Publication statusPublished - 26 Nov 2015

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