TY - JOUR
T1 - Anorexia nervosa polygenic risk, beyond diagnoses
T2 - relationship with adolescent disordered eating and behaviors in an Australian female twin population
AU - Curtis, Madeleine
AU - Colodro-Conde, Lucia
AU - Medland, Sarah E.
AU - Gordon, Scott
AU - Martin, Nicholas G.
AU - Wade, Tracey D.
AU - Cohen-Woods, Sarah
PY - 2024/10
Y1 - 2024/10
N2 - Background It is well established that there is a substantial genetic component to eating disorders (EDs). Polygenic risk scores (PRSs) can be used to quantify cumulative genetic risk for a trait at an individual level. Recent studies suggest PRSs for anorexia nervosa (AN) may also predict risk for other disordered eating behaviors, but no study has examined if PRS for AN can predict disordered eating as a global continuous measure. This study aimed to investigate whether PRS for AN predicted overall levels of disordered eating, or specific lifetime disordered eating behaviors, in an Australian adolescent female population. Methods PRSs were calculated based on summary statistics from the largest Psychiatric Genomics Consortium AN genome-wide association study to date. Analyses were performed using genome-wide complex trait analysis to test the associations between AN PRS and disordered eating global scores, avoidance of eating, objective bulimic episodes, self-induced vomiting, and driven exercise in a sample of Australian adolescent female twins recruited from the Australian Twin Registry (N = 383). Results After applying the false-discovery rate correction, the AN PRS was significantly associated with all disordered eating outcomes. Conclusions Findings suggest shared genetic etiology across disordered eating presentations and provide insight into the utility of AN PRS for predicting disordered eating behaviors in the general population. In the future, PRSs for EDs may have clinical utility in early disordered eating risk identification, prevention, and intervention.
AB - Background It is well established that there is a substantial genetic component to eating disorders (EDs). Polygenic risk scores (PRSs) can be used to quantify cumulative genetic risk for a trait at an individual level. Recent studies suggest PRSs for anorexia nervosa (AN) may also predict risk for other disordered eating behaviors, but no study has examined if PRS for AN can predict disordered eating as a global continuous measure. This study aimed to investigate whether PRS for AN predicted overall levels of disordered eating, or specific lifetime disordered eating behaviors, in an Australian adolescent female population. Methods PRSs were calculated based on summary statistics from the largest Psychiatric Genomics Consortium AN genome-wide association study to date. Analyses were performed using genome-wide complex trait analysis to test the associations between AN PRS and disordered eating global scores, avoidance of eating, objective bulimic episodes, self-induced vomiting, and driven exercise in a sample of Australian adolescent female twins recruited from the Australian Twin Registry (N = 383). Results After applying the false-discovery rate correction, the AN PRS was significantly associated with all disordered eating outcomes. Conclusions Findings suggest shared genetic etiology across disordered eating presentations and provide insight into the utility of AN PRS for predicting disordered eating behaviors in the general population. In the future, PRSs for EDs may have clinical utility in early disordered eating risk identification, prevention, and intervention.
KW - anorexia nervosa
KW - disordered eating
KW - eating disorder
KW - genetics
KW - polygenic risk
UR - http://www.scopus.com/inward/record.url?scp=85207952417&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/324715
UR - http://purl.org/au-research/grants/NHMRC/480420
UR - http://purl.org/au-research/grants/NHMRC/310667
U2 - 10.1017/S0033291724001727
DO - 10.1017/S0033291724001727
M3 - Article
AN - SCOPUS:85207952417
SN - 0033-2917
VL - 54
SP - 3646
EP - 3654
JO - Psychological Medicine
JF - Psychological Medicine
IS - 13
ER -