Anterior 90° Partial vs Nissen Fundoplication - 5 Year Follow-Up of a Single-Centre Randomised Trial

David Watson, Peter Devitt, Lorelle Smith, Glyn Jamieson

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    16 Citations (Scopus)


    Introduction: Nissen fundoplication can be followed by side effects, and this has driven modifications, including partial fundoplications. We previously reported early outcomes from a randomised trial of Nissen vs anterior 90° partial fundoplication. This paper reports 5-year follow-up outcomes to determine whether anterior 90° fundoplication achieves a satisfactory longer-term outcome. Methods: From February 1999 to August 2003, 79 patients were randomised to Nissen vs anterior 90° fundoplication. Patients were followed yearly using a standardized clinical questionnaire which included symptom scores to assess heartburn, dysphagia, other post-fundoplication side effects and overall satisfaction with the outcome. Five-year clinical outcomes were analysed. Results: Seventy-four patients were available for follow-up at 5 years. There were no significant differences for heartburn or satisfaction, although more patients used antisecretory medication after anterior 90° fundoplication (29. 7 vs 8. 1 %). Dysphagia was greater after Nissen fundoplication when measured by an analogue score for solid food and a composite dysphagia score. Symptoms of bloating were more common following Nissen fundoplication (80. 0 vs 32. 4 %), and less patients could eat a normal diet (78. 4 vs 94. 6 %). Re-operation was undertaken in four patients after Nissen fundoplication (dysphagia, three; hiatus hernia, one) vs three after anterior 90° fundoplication (recurrent reflux, three). Conclusions: At 5 years, anterior 90° partial fundoplication was associated with less side effects, offset by greater use of antisecretory medication. Reflux symptoms and overall satisfaction were similar to Nissen fundoplication. Laparoscopic anterior 90° partial fundoplication is an effective treatment for gastro-esophageal reflux.

    Original languageEnglish
    Pages (from-to)1653-1658
    Number of pages6
    JournalJournal of Gastrointestinal Surgery
    Issue number9
    Publication statusPublished - Sep 2012


    • Anterior partial fundoplication
    • Gastro-esophageal reflux disease
    • Laparoscopy
    • Nissen fundoplication
    • Randomised controlled trial


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