Anthracycline derivatives, a microbiological process for their preparation, and their use as medicaments [Ceased]

Christopher Franco (Inventor), Triptikumar Mukhopadhyay (Inventor), Desikan Kalyanapuram Rajagopal (Inventor), Ganguli Bimal Naresh (Inventor), Fehlhaber Hans-Wolfram (Inventor), Hans Peter Kraemer (Inventor)

Research output: Patent

Abstract

1. Claims for the Contracting States BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A Compound of the formula I see diagramm : EP0186807,P11,F2 in which R represents a sugar combination of the composition Roa-dF-Rod or Roa-Rod-Rod, where Roa represents rhodosamine, dF represents deoxyfucose and Rod represents rhodinose, and the physiologically acceptable acid addition salts thereof. 1. Claims for the contracting State AT A process for the preparation of compounds of the Formula I see diagramm : EP0186807,P11,F1 in which R represents a sugar combination of the composition Roa-dF-Rod or Roa-Rod-Rod, where Roa represents rhodosamine, dF represents deoxyfucose and Rod represents rhodinose, and the physiologically acceptable acid addition salts thereof, which comprises fermentation of the microorganism Streptomyces purpurascens DSM 2658 in a customary manner under aerobic conditions, in the presence of a nutrient medium, addition of a chemical inhibitor after a particular fermentation time, and isolation, from the culture liquid and the mycelium, of the compounds which have been formed, using organic solvents followed by chromatography in a customary manner.
Original languageEnglish
Patent numberAU 585918 B2
IPCC07C50/36,A61K31/12,A61K31/65,A61K31/70,A61K31/7028,A61K31/7034,A61K31/704,A61P31/04,A61P35/00,C07C45/00,C07C50/38,C07C67/00,C07H15/252,C12P15/00,C12P19/56,C12R1/465
Priority date18/12/84
Publication statusPublished - 29 Jun 1989
Externally publishedYes

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