Anti-amnesic effect of stevioside in scopolamine treated rats

Deepak Sharma, Munish Puri, Ashok Tiwary, Nirmal Singh, Amteshwar Jaggi

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    The present study was undertaken to explore the potential of stevioside in memory dysfunction of rats. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) in animals. Morris water maze (MWM) test was employed to assess learning and memory. Brain acetylcholinestrase enzyme (AChE) activity was measured to assess the central cholinergic activity. The levels of brain thiobarbituric acid-reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess the degree of oxidative stress. Scopolamine administration induced significant impairment of learning and memory in rats, as indicated by a marked decrease in MWM performance. Scopolamine administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS and decrease in GSH) levels. Pretreatment of stevioside (250 mg/kg dose orally) significantly reversed scopolamine-induced learning and memory deficits along with attenuation of scopolamine-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that stevioside exerts a memory-preservative effect in cognitive deficits of rats possibly through its multiple actions.

    Original languageEnglish
    Pages (from-to)164-167
    Number of pages4
    JournalINDIAN JOURNAL OF PHARMACOLOGY
    Volume42
    Issue number3
    DOIs
    Publication statusPublished - 1 May 2010

    Keywords

    • Memory
    • Morris water-maze
    • scopolamine
    • stevioside

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