Anti-calreticulin Segregates anti-Ro Sera in Systemic Lupus Erythematosus: Anti-Calreticulin Is Present in Sera With anti-Ro Alone but Not in anti-Ro Sera With anti-La or Anti-Ribonucleoprotein

R. H. Scofield, D. M. Racila, T. P. Gordon, B. T. Kurien, R. D. Sontheimer

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective. To examine a well characterized group of patients with systemic lupus erythematosus (SLE) for anti-calreticulin. Methods. The sera of 77 patients with SLE were studied by immunodiffusion, solid phase immunoassay, and immunoblot for antibodies against ribonucleoprotein (RNP) autoantigens and calreticulin. Results. Thirty-five had anti-calreticulin and 40 had anti-60 kDa Ro. There was no association of anti-60 kDa Ro and anti- calreticulin. However, among anti-60 kDa Ro positive sera that also contained either anti-La or anti-RNP, none of 18 had anti-calreticulin. All the remaining sera with anti-60 kDa Ro had anti-calreticulin and anti-52 kDa Ro. Conclusion. Anti-60 kDa Ro patients with SLE can be divided into those with anti-60 kDa Ro and either anti-La or anti-RNP or those with anti-60 kDa Ro, anti-52 kDa Ro, and anti-calreticulin.

Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalJournal of Rheumatology
Volume27
Issue number1
Publication statusPublished - Jan 2000
Externally publishedYes

Keywords

  • Autoantibodies
  • Autoantigens
  • Calreticulin
  • Ribonucleoproteins
  • Systemic lupus erythematosus

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