Abstract
Objective. To examine a well characterized group of patients with systemic lupus erythematosus (SLE) for anti-calreticulin. Methods. The sera of 77 patients with SLE were studied by immunodiffusion, solid phase immunoassay, and immunoblot for antibodies against ribonucleoprotein (RNP) autoantigens and calreticulin. Results. Thirty-five had anti-calreticulin and 40 had anti-60 kDa Ro. There was no association of anti-60 kDa Ro and anti- calreticulin. However, among anti-60 kDa Ro positive sera that also contained either anti-La or anti-RNP, none of 18 had anti-calreticulin. All the remaining sera with anti-60 kDa Ro had anti-calreticulin and anti-52 kDa Ro. Conclusion. Anti-60 kDa Ro patients with SLE can be divided into those with anti-60 kDa Ro and either anti-La or anti-RNP or those with anti-60 kDa Ro, anti-52 kDa Ro, and anti-calreticulin.
Original language | English |
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Pages (from-to) | 128-134 |
Number of pages | 7 |
Journal | Journal of Rheumatology |
Volume | 27 |
Issue number | 1 |
Publication status | Published - Jan 2000 |
Externally published | Yes |
Keywords
- Autoantibodies
- Autoantigens
- Calreticulin
- Ribonucleoproteins
- Systemic lupus erythematosus