Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles

M. Hasanzadeh Kafshgari; B. Delalat; F. J. Harding; A. Cavallaro; E. Mäkilä; J. Salonen; K. Vasilev; N. H. Voelcker

doi:10.1039/c5tb02551f

Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles

M. Hasanzadeh Kafshgari, B. Delalat, F. J. Harding, A. Cavallaro, E. Mäkilä, J. Salonen, K. Vasilev, N. H. Voelcker

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36 Citations (Scopus)

Abstract

In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.

Original language	English
Pages (from-to)	2051-2058
Number of pages	8
Journal	JOURNAL OF MATERIALS CHEMISTRY B
Volume	4
Issue number	11
DOIs	https://doi.org/10.1039/c5tb02551f
Publication status	Published - 21 Mar 2016
Externally published	Yes

Keywords

Nanoparticles
Porous silicon nanoparticles (pSiNPs)
Wound care
Patient outcomes

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title = "Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles",

abstract = "In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.",

keywords = "Nanoparticles, Porous silicon nanoparticles (pSiNPs), Wound care, Patient outcomes",

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AU - Hasanzadeh Kafshgari, M.

AU - Delalat, B.

AU - Harding, F. J.

AU - Cavallaro, A.

AU - Mäkilä, E.

AU - Salonen, J.

AU - Vasilev, K.

AU - Voelcker, N. H.

PY - 2016/3/21

Y1 - 2016/3/21

N2 - In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.

AB - In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.

KW - Nanoparticles

KW - Porous silicon nanoparticles (pSiNPs)

KW - Wound care

KW - Patient outcomes

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Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles

Abstract

Keywords

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