Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles

M. Hasanzadeh Kafshgari, B. Delalat, F. J. Harding, A. Cavallaro, E. Mäkilä, J. Salonen, K. Vasilev, N. H. Voelcker

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.

Original languageEnglish
Pages (from-to)2051-2058
Number of pages8
JournalJOURNAL OF MATERIALS CHEMISTRY B
Volume4
Issue number11
DOIs
Publication statusPublished - 21 Mar 2016
Externally publishedYes

Keywords

  • Nanoparticles
  • Porous silicon nanoparticles (pSiNPs)
  • Wound care
  • Patient outcomes

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