Antibacterial surfaces for biomedical devices

Krasimir Vasilev, Jessica Cook, Hans J. Griesser

Research output: Contribution to journalReview articlepeer-review

390 Citations (Scopus)

Abstract

Despite considerable research and development efforts, the problem of infections related to biomedical devices and implants persists. Bacteria evidently can readily colonize surfaces of synthetic materials, such as those used for the fabrication of catheters, hip and knee implants, and many other devices. As the growing colony encapsulates itself with a protective exocellular bacterial polysaccharide layer, the biofilm becomes much harder to combat than circulating bacteria. Thus, there is a strong need to mitigate bacterial colonization by equipping the surfaces of biomedical devices and implants with features such as surface chemistry and surface roughness that are unfavorable for bacterial attachment. Here we review a number of strategies used for the design of antibacterial coatings. We also discuss specific issues that arise from using various types of coatings.

Original languageEnglish
Pages (from-to)553-567
Number of pages15
JournalExpert Review of Medical Devices
Volume6
Issue number5
DOIs
Publication statusPublished - Sep 2009
Externally publishedYes

Keywords

  • Antibacterial coating
  • Controlled release
  • Furanone
  • Infection
  • Medical devices
  • Polymer film
  • Quaternary ammonium compound
  • Silver
  • Surface grafting

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