TY - JOUR
T1 - Antibiotics with anaerobic coverage are associated with disproportionate gut microbiota disruption in ICU patients
T2 - a multi-centre, longitudinal observational study
AU - Taylor, Steven L.
AU - Rogers, Geraint B.
AU - Papanicolas, Lito E.
AU - MOCI Study Group Investigators
AU - Miller, Sophie J.
AU - Richard, Alyson
AU - Manning, Sarah K.
AU - Elms, Levi
AU - Vasil, Egi
AU - Ashokan, Anushia
AU - Chapple, Lee-anne
AU - Reddi, Benjamin
AU - Bihari, Shailesh
PY - 2025/10
Y1 - 2025/10
N2 - Infectious complications are a major contributor to mortality in those admitted to intensive care unit (ICU). As a result, urgent treatment with empirical, broad-spectrum antibiotics is common. Selective digestive decontamination (SDD), where prophylactic antibiotics and antifungals are administered directly to the gut, have also been trialled to prevent sepsis, with varying success
AB - Infectious complications are a major contributor to mortality in those admitted to intensive care unit (ICU). As a result, urgent treatment with empirical, broad-spectrum antibiotics is common. Selective digestive decontamination (SDD), where prophylactic antibiotics and antifungals are administered directly to the gut, have also been trialled to prevent sepsis, with varying success
KW - antibiotics
KW - Anaerobic co-digestion
KW - infectious complications
KW - intensive care unit (ICU)
KW - broad-spectrum antibiotics
KW - selective digestion decontamination (SDD)
UR - http://www.scopus.com/inward/record.url?scp=105017987190&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/2008625
UR - http://purl.org/au-research/grants/NHMRC/1155179
U2 - 10.1007/s00134-025-08106-6
DO - 10.1007/s00134-025-08106-6
M3 - Letter
C2 - 40982013
AN - SCOPUS:105017987190
SN - 0342-4642
VL - 51
SP - 1940
EP - 1943
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 10
ER -