Anticoagulation and prosthetic heart valves: To the Editor [Reply]

Jalal N. Saour, Jens Otto Siegk, Layla A.r. Mammo, Alexander S. Gallus

Research output: Contribution to journalLetterpeer-review


To the Editor: The work of Saour et al. on anticoagulation in patients with prosthetic heart valves (Feb. 15 issue)1 is to be commended for its attempt to address the problem of the appropriate intensity of anticoagulation in such patients. The authors concluded that “moderate-intensity” anticoagulation with coumadin (prothrombin-time ratio, 1.3 to 1.7) is associated with no greater frequency of thromboembolic events than “high-intensity” anticoagulation (prothrombin-time ratio, 2.3 to 2.7), but with fewer hemorrhagic complications. However, the data for thromboembolic events shown in Figure 1 of their paper suggest an entirely different conclusion. If the embolic data are analyzed in.

Original languageEnglish
Pages (from-to)756-757
Number of pages2
JournalNew England Journal of Medicine
Issue number11
Publication statusPublished - 13 Sept 1990
Externally publishedYes


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