Antimicrobial dyes and mechanosensitive channels

Ramiz Boulos

    Research output: Contribution to journalReview articlepeer-review

    11 Citations (Scopus)

    Abstract

    The search for new and effective antimicrobial agents has never been as important; however, since the discovery of antibiotics, exploring the antimicrobial activity of dyes has been forgotten. Antimicrobial dyes are an untapped resource and have the ability to potentially combat the spread of drug-resistant bacteria either alone or as antimicrobial adjuvants. The mechanosensitive ion channel of large conductance (MscL) is highly conserved and ubiquitous in bacterial species. There is evidence to suggest that at least one triphenylmethane dye acts through the highly conserved MscL channel and combining the two approaches of exploring the mechanism of action of other triphenylmethane dyes or antimicrobial dyes in general and the novel MscL target provides a new opportunity for further exploration.

    Original languageEnglish
    Pages (from-to)155-167
    Number of pages13
    JournalAntonie Van Leeuwenhoek International Journal of General and Molecular Microbiology
    Volume104
    Issue number2
    DOIs
    Publication statusPublished - Aug 2013

    Keywords

    • Antibiotic resistance
    • Drug discovery
    • Drug pumps
    • Dyes
    • MRSA
    • MscL

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