Antimicrobial graphene-based coatings for biomedical implant applications

Jesus Romo-Rico; Richard Bright; Smriti Murali Krishna; Krasimir Vasilev; Jonathan Golledge; Mohan V. Jacob

doi:10.1016/j.cartre.2023.100282

Antimicrobial graphene-based coatings for biomedical implant applications

Jesus Romo-Rico, Richard Bright, Smriti Murali Krishna, Krasimir Vasilev, Jonathan Golledge, Mohan V. Jacob

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Implant-associated infections (IAI) cause significant health issues and healthcare costs. In this research, we deposited graphene (Gr) on a medical-grade cobalt-chromium (CoCr) alloy surface by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) using Origanum vulgare as a precursor material. The deposition of Gr on the CoCr was confirmed using Raman spectroscopy and X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The biocompatibility and antibacterial properties of CoCr-Gr were investigated. CoCr-Gr was biocompatible and promoted cell adhesion and spreading of RAW 267.4 macrophage cells. CoCr-Gr were antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa and inhibited P. aeruginosa attachment. The results indicate that CoCr-Gr could be used as a potential antibacterial coating material for implantable devices.

Original language	English
Article number	100282
Number of pages	8
Journal	Carbon Trends
Volume	12
Early online date	4 Jul 2023
DOIs	https://doi.org/10.1016/j.cartre.2023.100282
Publication status	Published - Sept 2023

Keywords

Antimicrobial
Biocompatible
Coatings
Graphene
Implant

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title = "Antimicrobial graphene-based coatings for biomedical implant applications",

abstract = "Implant-associated infections (IAI) cause significant health issues and healthcare costs. In this research, we deposited graphene (Gr) on a medical-grade cobalt-chromium (CoCr) alloy surface by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) using Origanum vulgare as a precursor material. The deposition of Gr on the CoCr was confirmed using Raman spectroscopy and X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The biocompatibility and antibacterial properties of CoCr-Gr were investigated. CoCr-Gr was biocompatible and promoted cell adhesion and spreading of RAW 267.4 macrophage cells. CoCr-Gr were antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa and inhibited P. aeruginosa attachment. The results indicate that CoCr-Gr could be used as a potential antibacterial coating material for implantable devices.",

keywords = "Antimicrobial, Biocompatible, Coatings, Graphene, Implant",

author = "Jesus Romo-Rico and Richard Bright and Krishna, {Smriti Murali} and Krasimir Vasilev and Jonathan Golledge and Jacob, {Mohan V.}",

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doi = "10.1016/j.cartre.2023.100282",

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T1 - Antimicrobial graphene-based coatings for biomedical implant applications

AU - Romo-Rico, Jesus

AU - Bright, Richard

AU - Krishna, Smriti Murali

AU - Vasilev, Krasimir

AU - Golledge, Jonathan

AU - Jacob, Mohan V.

PY - 2023/9

Y1 - 2023/9

N2 - Implant-associated infections (IAI) cause significant health issues and healthcare costs. In this research, we deposited graphene (Gr) on a medical-grade cobalt-chromium (CoCr) alloy surface by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) using Origanum vulgare as a precursor material. The deposition of Gr on the CoCr was confirmed using Raman spectroscopy and X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The biocompatibility and antibacterial properties of CoCr-Gr were investigated. CoCr-Gr was biocompatible and promoted cell adhesion and spreading of RAW 267.4 macrophage cells. CoCr-Gr were antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa and inhibited P. aeruginosa attachment. The results indicate that CoCr-Gr could be used as a potential antibacterial coating material for implantable devices.

AB - Implant-associated infections (IAI) cause significant health issues and healthcare costs. In this research, we deposited graphene (Gr) on a medical-grade cobalt-chromium (CoCr) alloy surface by radiofrequency plasma-enhanced chemical vapor deposition (RF-PECVD) using Origanum vulgare as a precursor material. The deposition of Gr on the CoCr was confirmed using Raman spectroscopy and X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The biocompatibility and antibacterial properties of CoCr-Gr were investigated. CoCr-Gr was biocompatible and promoted cell adhesion and spreading of RAW 267.4 macrophage cells. CoCr-Gr were antibacterial against Staphylococcus aureus and Pseudomonas aeruginosa and inhibited P. aeruginosa attachment. The results indicate that CoCr-Gr could be used as a potential antibacterial coating material for implantable devices.

KW - Antimicrobial

KW - Biocompatible

KW - Coatings

KW - Graphene

KW - Implant

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UR - http://purl.org/au-research/grants/NHMRC/1194466

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JO - Carbon Trends

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ER -

Antimicrobial graphene-based coatings for biomedical implant applications

Abstract

Keywords

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