Antimicrobial Polymethacrylates Synthesized as Mimics of Tryptophan-Rich Cationic Peptides

Katherine E.S. Locock; Thomas D. Michl; Natalie Stevens; John D. Hayball; Krasimir Vasilev; Almar Postma; Hans J. Griesser; Laurence Meagher; Matthias Haeussler

doi:10.1021/mz5001527

Antimicrobial Polymethacrylates Synthesized as Mimics of Tryptophan-Rich Cationic Peptides

Katherine E.S. Locock, Thomas D. Michl, Natalie Stevens, John D. Hayball, Krasimir Vasilev, Almar Postma, Hans J. Griesser, Laurence Meagher, Matthias Haeussler

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

This study describes a facile and high yielding route to two series of polymethacrylates inspired by the naturally occurring, tryptophan-rich cationic antimicrobial polymers. Appropriate optimization of indole content within each gave rise to polymers with high potency against Staphylococcus epidermidis (e.g., PGI-3 minimum inhibitory concentration (MIC) = 12 μg/mL) and the methicillin-resistant strain of Staphylococcus aureus (e.g., PGI-3 MIC = 47 μg/mL) with minimal toxicity toward human red blood cells. Future work will be directed toward understanding the cooperative roles that the cationic and indole pendant groups have for the mechanism of these polymers.

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	ACS Macro Letters
Volume	3
Issue number	4
DOIs	https://doi.org/10.1021/mz5001527
Publication status	Published - 15 Apr 2014
Externally published	Yes

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abstract = "This study describes a facile and high yielding route to two series of polymethacrylates inspired by the naturally occurring, tryptophan-rich cationic antimicrobial polymers. Appropriate optimization of indole content within each gave rise to polymers with high potency against Staphylococcus epidermidis (e.g., PGI-3 minimum inhibitory concentration (MIC) = 12 μg/mL) and the methicillin-resistant strain of Staphylococcus aureus (e.g., PGI-3 MIC = 47 μg/mL) with minimal toxicity toward human red blood cells. Future work will be directed toward understanding the cooperative roles that the cationic and indole pendant groups have for the mechanism of these polymers.",

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AU - Locock, Katherine E.S.

AU - Michl, Thomas D.

AU - Stevens, Natalie

AU - Hayball, John D.

AU - Vasilev, Krasimir

AU - Postma, Almar

AU - Griesser, Hans J.

AU - Meagher, Laurence

AU - Haeussler, Matthias

PY - 2014/4/15

Y1 - 2014/4/15

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AB - This study describes a facile and high yielding route to two series of polymethacrylates inspired by the naturally occurring, tryptophan-rich cationic antimicrobial polymers. Appropriate optimization of indole content within each gave rise to polymers with high potency against Staphylococcus epidermidis (e.g., PGI-3 minimum inhibitory concentration (MIC) = 12 μg/mL) and the methicillin-resistant strain of Staphylococcus aureus (e.g., PGI-3 MIC = 47 μg/mL) with minimal toxicity toward human red blood cells. Future work will be directed toward understanding the cooperative roles that the cationic and indole pendant groups have for the mechanism of these polymers.

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Antimicrobial Polymethacrylates Synthesized as Mimics of Tryptophan-Rich Cationic Peptides

Abstract

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