Antimicrobial Polymethacrylates Synthesized as Mimics of Tryptophan-Rich Cationic Peptides

Katherine E.S. Locock, Thomas D. Michl, Natalie Stevens, John D. Hayball, Krasimir Vasilev, Almar Postma, Hans J. Griesser, Laurence Meagher, Matthias Haeussler

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

This study describes a facile and high yielding route to two series of polymethacrylates inspired by the naturally occurring, tryptophan-rich cationic antimicrobial polymers. Appropriate optimization of indole content within each gave rise to polymers with high potency against Staphylococcus epidermidis (e.g., PGI-3 minimum inhibitory concentration (MIC) = 12 μg/mL) and the methicillin-resistant strain of Staphylococcus aureus (e.g., PGI-3 MIC = 47 μg/mL) with minimal toxicity toward human red blood cells. Future work will be directed toward understanding the cooperative roles that the cationic and indole pendant groups have for the mechanism of these polymers.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalACS Macro Letters
Volume3
Issue number4
DOIs
Publication statusPublished - 15 Apr 2014
Externally publishedYes

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