Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

Eliza James, Paul Eggers, Alan Harvey, Sarah Dunlop, Melinda Fitzgerald, Keith Stubbs, Colin Raston

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3+ head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.

    Original languageEnglish
    Pages (from-to)6108-6112
    Number of pages5
    JournalOrganic and Biomolecular Chemistry
    Volume11
    Issue number36
    DOIs
    Publication statusPublished - 28 Sep 2013

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