Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

Eliza James; Paul Eggers; Alan Harvey; Sarah Dunlop; Melinda Fitzgerald; Keith Stubbs; Colin Raston

doi:10.1039/c3ob41178h

Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

Eliza James, Paul Eggers, Alan Harvey, Sarah Dunlop, Melinda Fitzgerald, Keith Stubbs, Colin Raston

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO₃H₂ or NMe₃⁺ head groups. Using PC12 cells and three stressors (H₂O₂, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.

Original language	English
Pages (from-to)	6108-6112
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	36
DOIs	https://doi.org/10.1039/c3ob41178h
Publication status	Published - 28 Sep 2013

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abstract = "Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3+ head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.",

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AU - Eggers, Paul

AU - Harvey, Alan

AU - Dunlop, Sarah

AU - Fitzgerald, Melinda

AU - Stubbs, Keith

AU - Raston, Colin

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AB - Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3+ head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.

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ER -

Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

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