Abstract
Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3+ head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.
Original language | English |
---|---|
Pages (from-to) | 6108-6112 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 11 |
Issue number | 36 |
DOIs | |
Publication status | Published - 28 Sep 2013 |