TY - GEN
T1 - Antioxidant Treatment Does Not Prevent Chronic Hypoxia-Induced Respiratory Muscle Impairment in Developing Rats
AU - Carberry, Jayne
AU - Bradford, Aidan
AU - O'Halloran, Ken D.
PY - 2010
Y1 - 2010
N2 -
Litters of rats were exposed to normobaric normoxia or hypobaric hypoxia (P
B
= 450 mmHg) for 7 days at 3 different time points during early development (postnatal day (P)1, P6 & P11). A separate litter exposed to hypoxia at P11 was treated with the antioxidant Tempol (100 mg/kg) given by oral administration daily starting at P8. At P19, sternohyoid and diaphragm muscles were removed and isolated muscle bundles were mounted isometrically in physiological salt solution at 30°C in vitro. Fatigue was assessed in response to repeated stimulation (40 Hz) every 2 s for 5 min. Fatigue index was measured. Chronic hypoxia decreased sternohyoid, but not diaphragm, muscle endurance. Tempol treatment did not prevent hypoxia-induced muscle plasticity, suggesting that reactive oxygen species are not implicated in hypoxia-induced muscle dysfunction.
AB -
Litters of rats were exposed to normobaric normoxia or hypobaric hypoxia (P
B
= 450 mmHg) for 7 days at 3 different time points during early development (postnatal day (P)1, P6 & P11). A separate litter exposed to hypoxia at P11 was treated with the antioxidant Tempol (100 mg/kg) given by oral administration daily starting at P8. At P19, sternohyoid and diaphragm muscles were removed and isolated muscle bundles were mounted isometrically in physiological salt solution at 30°C in vitro. Fatigue was assessed in response to repeated stimulation (40 Hz) every 2 s for 5 min. Fatigue index was measured. Chronic hypoxia decreased sternohyoid, but not diaphragm, muscle endurance. Tempol treatment did not prevent hypoxia-induced muscle plasticity, suggesting that reactive oxygen species are not implicated in hypoxia-induced muscle dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=77952304356&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-5692-7_53
DO - 10.1007/978-1-4419-5692-7_53
M3 - Conference contribution
SN - 9781441956910
T3 - Advances in Experimental Medicine and Biology
SP - 263
EP - 266
BT - New Frontiers in Respiratory Control
A2 - Homma, Ikuo
A2 - Onimaru, Hiroshi
A2 - Fukuchi, Yoshinosuke
PB - Springer
T2 - XIth annual Oxford conference on modeling and control of breathing
Y2 - 23 July 2009
ER -