Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat

Leon C. Terry; John O. Willoughby; Paul Brazeau; Joseph B. Martin; Yogesh Patel

doi:10.1126/science.1257793

Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat

Leon C. Terry, John O. Willoughby, Paul Brazeau, Joseph B. Martin, Yogesh Patel

Research output: Contribution to journal › Article › peer-review

161 Citations (Scopus)

Abstract

Plasma growth hormone levels fall and remain low for several hours after stress in the rat. When antiserums to somatostatin are administered to rats prior to stress, growth hormone secretory pulses are partially restored. The results provide evidence that circulating somatostatin plays a prominent role in stress-induced inhibition of growth hormone secretion in the rat.

Original language	English
Pages (from-to)	565-567
Number of pages	3
Journal	Science
Volume	192
Issue number	4239
DOIs	https://doi.org/10.1126/science.1257793
Publication status	Published - 7 May 1976
Externally published	Yes

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title = "Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat",

abstract = "Plasma growth hormone levels fall and remain low for several hours after stress in the rat. When antiserums to somatostatin are administered to rats prior to stress, growth hormone secretory pulses are partially restored. The results provide evidence that circulating somatostatin plays a prominent role in stress-induced inhibition of growth hormone secretion in the rat.",

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AU - Brazeau, Paul

AU - Martin, Joseph B.

AU - Patel, Yogesh

PY - 1976/5/7

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AB - Plasma growth hormone levels fall and remain low for several hours after stress in the rat. When antiserums to somatostatin are administered to rats prior to stress, growth hormone secretory pulses are partially restored. The results provide evidence that circulating somatostatin plays a prominent role in stress-induced inhibition of growth hormone secretion in the rat.

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JO - Science

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Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat

Abstract

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