Antivirals for children with influenza: Current evidence

Joshua Francis, Christopher Blyth

    Research output: Contribution to journalArticle

    Abstract

    The global burden of influenza virus infection is considerable, especially in young children, the elderly and those with underlying medical conditions. Young children are at greatest risk of requiring hospital admission with influenza virus infection. Effective antiviral treatment and prophylaxis strategies are available. Adamantanes, neuraminidase inhibitors and ribavirin all have antiviral activity. The neuraminidase inhibitors oseltamivir and zanamivir are most frequently prescribed. Neuraminidase inhibitors reduce length of illness and severity and are generally well tolerated. Antiviral resistance is increasing globally. Antiviral resistance can occur de novo or following antiviral exposure. The incidence varies significantly between different drug classes and influenza strains. Despite increasing concern, most circulating influenza viruses remain sensitive to neuraminidase inhibitors.

    Original languageEnglish
    Pages (from-to)55-60
    Number of pages6
    JournalJournal of Pediatric Infectious Diseases
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - 2012

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