Apparent resistance to hypotensive effect of clonidine

L. M.H. Wing, D. S. Davies, H. J. Dargie, C. T. Dollery

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Clonidine failed to reduce the blood pressures of two patients with essential hypertension. One was given 5.4 mg/day and the other 6 mg/day, and their respective peak plasma clonidine concentrations were 26.2 ng/ml and 14.4 ng/ml. Several months after the end of clonidine treatment a single oral dose of 0.3 mg of clonidine produced maximum falls in blood pressure of 30/22 mm Hg and 88/41 mm Hg with peak plasma clonidine concentrations of 1.4 ng/ml and 0–9 ng/ml. Resistance to the hypotensive effect of high doses of clonidine may be due to stimulation of peripheral alpha-adrenoceptors causing vasoconstriction, which maintains a raised blood pressure.

Original languageEnglish
Pages (from-to)136-138
Number of pages3
JournalBritish Medical Journal
Issue number6054
Publication statusPublished - Jan 1977
Externally publishedYes


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