TY - JOUR
T1 - Appendiceal neoplasm incidence and mortality rates are on the rise in Australia
AU - Mikaeel, Reger R.
AU - Young, Joanne P.
AU - Hardingham, Jennifer E.
AU - Tapia Rico, Gonzalo
AU - Hewett, Peter J.
AU - Symonds, Erin L.
AU - Edwards, Suzanne
AU - Smith, Eric
AU - Tomita, Yoko
AU - Uylaki, Wendy
AU - Horsnell, Mehgan
AU - Price, Timothy J.
PY - 2021
Y1 - 2021
N2 - Objectives: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia. Methods: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y). Results: Incidence and mortality rates of ANs increased significantly across both genders and age groups. Incidence rates increased by 415%, from 0.40/100 000 population in 1982 to 2.06/100 000 in 2013. Overall mortality rates increased by 130%, from 0.057/100 000 during 1982–1985 to 0.131/100 000 during 2010–2013. Controlling for age group and gender, the incidence rates increased by 20% every four years (Incidence rate ratio (IRR) = 1.20, 95% confidence interval (CI): 1.17, 1.23, global P value<0.0001), and controlling for age, the mortality rates increased by 8% every four years (IRR = 1.08, 95% CI: 1.00, 1.17, global P-value = 0.0401). Conclusion: The increasing use of CT scanning, improvements in pathological assessment of the appendix, and the growing aging population may have contributed in part to the apparent rise in the incidence of ANs.
AB - Objectives: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia. Methods: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y). Results: Incidence and mortality rates of ANs increased significantly across both genders and age groups. Incidence rates increased by 415%, from 0.40/100 000 population in 1982 to 2.06/100 000 in 2013. Overall mortality rates increased by 130%, from 0.057/100 000 during 1982–1985 to 0.131/100 000 during 2010–2013. Controlling for age group and gender, the incidence rates increased by 20% every four years (Incidence rate ratio (IRR) = 1.20, 95% confidence interval (CI): 1.17, 1.23, global P value<0.0001), and controlling for age, the mortality rates increased by 8% every four years (IRR = 1.08, 95% CI: 1.00, 1.17, global P-value = 0.0401). Conclusion: The increasing use of CT scanning, improvements in pathological assessment of the appendix, and the growing aging population may have contributed in part to the apparent rise in the incidence of ANs.
KW - Appendiceal neoplasms
KW - incidence rates
KW - mortality rates
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85095768594&partnerID=8YFLogxK
U2 - 10.1080/17474124.2021.1832467
DO - 10.1080/17474124.2021.1832467
M3 - Article
C2 - 33022181
AN - SCOPUS:85095768594
SN - 1747-4124
VL - 15
SP - 203
EP - 210
JO - Expert Review of Gastroenterology and Hepatology
JF - Expert Review of Gastroenterology and Hepatology
IS - 2
ER -