Application of solid-phase microextraction to the profiling of an illicit drug: Manufacturing impurities in illicit 4-methoxyamphetamine

John C. Coumbaros, K. Paul Kirkbride, Gunter Klass

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

This article describes the application of solid-phase microextraction (SPME) to the recovery of manufacturing by-products and impurities from an illicit drug seizure. The preparation chosen for examination using this technique contained 4-methoxyamphetamine, an hallucinogenic amphetamine that has been encountered frequently in South Australia. Compounds found in the PMA preparation included 4-methoxyphenol, 4-methoxybenzaldehyde, 4- methoxyphenyl-2-propanone, 4-methoxyphenyl-2-propanol, 4- methoxyphenylpropene, and (tentatively) 4-methyl-5-(4'-methoxyphenyl) pyrimidine. The presence of these compounds suggests that the active drug was prepared from 4-methoxybenzaldehyde via 4-methoxyphenyl-2-propanone using a Leuckardt inductive amination. In this instance, SPME was found to be a simple, rapid, and nondestructive recovery technique that gave results complementary to those provided by conventional liquid-liquid extraction. There is an indication that SPME might find application in profiling of illicit drugs.

Original languageEnglish
Pages (from-to)1237-1242
Number of pages6
JournalJournal of Forensic Sciences
Volume44
Issue number6
Publication statusPublished - 1 Nov 1999
Externally publishedYes

Keywords

  • 4-methoxyamphetamine
  • Chemistry
  • Forensic science
  • Hallucinogen
  • Profiling
  • Solid-phase microextraction
  • Substance abuse

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