Applications of Palladium-Mediated Eliminations in Natural Product Synthesis

Anik Jana; Thomas P. Nicholls; Curtis C. Ho; Alex C. Bissember

doi:10.1002/chem.202503015

Applications of Palladium-Mediated Eliminations in Natural Product Synthesis

Anik Jana, Thomas P. Nicholls, Curtis C. Ho, Alex C. Bissember

Research output: Contribution to journal › Review article › peer-review

Abstract

This review presents and examines a selection of case studies that showcase powerful and enabling applications of palladium-mediated elimination-type transformations in facilitating the synthesis of structurally diverse natural products and related targets. Classes of reactions include palladium-catalyzed dehydrohalogenations (encompassing asymmetric variants), and reductive stereoselective allylic transpositions, all of which typically proceed under mild conditions.

Original language	English
Article number	e03015
Number of pages	10
Journal	Chemistry-A European Journal
DOIs	https://doi.org/10.1002/chem.202503015
Publication status	E-pub ahead of print - 31 Dec 2025

Keywords

β-hydride elimination
π-allylpalladium species
natural products
palladium catalysis
total synthesis

Access to Document

10.1002/chem.202503015Licence: In Copyright

Cite this

@article{6ce07452e20f4bad84d1d9c3e85ae62b,

title = "Applications of Palladium-Mediated Eliminations in Natural Product Synthesis",

abstract = "This review presents and examines a selection of case studies that showcase powerful and enabling applications of palladium-mediated elimination-type transformations in facilitating the synthesis of structurally diverse natural products and related targets. Classes of reactions include palladium-catalyzed dehydrohalogenations (encompassing asymmetric variants), and reductive stereoselective allylic transpositions, all of which typically proceed under mild conditions.",

keywords = "β-hydride elimination, π-allylpalladium species, natural products, palladium catalysis, total synthesis",

author = "Anik Jana and Nicholls, {Thomas P.} and Ho, {Curtis C.} and Bissember, {Alex C.}",

year = "2025",

month = dec,

day = "31",

doi = "10.1002/chem.202503015",

language = "English",

journal = "Chemistry-A European Journal",

issn = "1521-3765",

publisher = "John Wiley & Sons, Inc",

}

TY - JOUR

T1 - Applications of Palladium-Mediated Eliminations in Natural Product Synthesis

AU - Jana, Anik

AU - Nicholls, Thomas P.

AU - Ho, Curtis C.

AU - Bissember, Alex C.

PY - 2025/12/31

Y1 - 2025/12/31

N2 - This review presents and examines a selection of case studies that showcase powerful and enabling applications of palladium-mediated elimination-type transformations in facilitating the synthesis of structurally diverse natural products and related targets. Classes of reactions include palladium-catalyzed dehydrohalogenations (encompassing asymmetric variants), and reductive stereoselective allylic transpositions, all of which typically proceed under mild conditions.

AB - This review presents and examines a selection of case studies that showcase powerful and enabling applications of palladium-mediated elimination-type transformations in facilitating the synthesis of structurally diverse natural products and related targets. Classes of reactions include palladium-catalyzed dehydrohalogenations (encompassing asymmetric variants), and reductive stereoselective allylic transpositions, all of which typically proceed under mild conditions.

KW - β-hydride elimination

KW - π-allylpalladium species

KW - natural products

KW - palladium catalysis

KW - total synthesis

UR - http://www.scopus.com/inward/record.url?scp=105026407099&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/ARC/DE250100525

U2 - 10.1002/chem.202503015

DO - 10.1002/chem.202503015

M3 - Review article

SN - 1521-3765

JO - Chemistry-A European Journal

JF - Chemistry-A European Journal

M1 - e03015

ER -

Applications of Palladium-Mediated Eliminations in Natural Product Synthesis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this