Abstract
Purpose: To investigate whether motion coherence thresholds are
associated with altered retinal signaling in autism spectrum disorder
(ASD).
Methods: Motion coherence thresholds were assessed in a cohort of
40 ASD subjects and in 16 ASD siblings (aged 6–25 years) using
LumitrackTM software. Moving stimuli were either white dots on a
black background or black dots on a white background. ASD subject
data were compared with LumitrackTM motion coherence reference
limits, compiled from 97 typically developed individuals (aged
4–25 years). Light-adapted (LA) ERGs were recorded in the ASD
individuals and their siblings using the RETeval (LKC Technologies
Inc., Gaithersburg MD, USA). A Troland-based, random nine-step,
full-field flash series and ISCEV standard LA 3.0 cd s/m2 presented at
2/s on a 30 cd/m2 background was performed on both eyes. The aand
b-wave amplitudes and timing were measured for comparisons
between different groups.
Results: Motion coherence thresholds were elevated with mean
threshold 44% in both ASD (range 25–82%) and their sibling (range
25–85%) groups. However, 55% (22/40) of ASD subjects and 38%
(6/16) of their siblings had raised thresholds compared to the upper
reference limit of typically developed individuals which was 23%
(95th CI), with mean 9%. The mean ASD elevated threshold for black
dots on white background was 45% in both ASD and their siblings,
whereas those for white dots on black background were 42% and 44%
in ASD and siblings, respectively. The mean of the timing and
amplitudes of the a- and b-waves of LA3 ERGs did not significantly
differ between ASD and siblings with elevated motion coherence
thresholds. Mean LA3 ERG a-wave amplitudes were 7 lV (range
4–12 lV) for ASD subjects and 8 lV (range 3–12 lV) for their
siblings. Mean LA3 ERG b-wave amplitudes were 33 lV (range
16–50 lV) for ASD subjects and 35 lV for their siblings (range
27–51 lV). Mean LA3 ERG a-wave peak times were 12 ms for ASD
and 11 ms for their siblings and those of b-waves were 29 ms in ASD
compared with 28 ms in the sibling group.
Conclusions: The elevated motion coherence thresholds do not
appear to be associated with reported altered retinal signaling measured
by LA electroretinography.
associated with altered retinal signaling in autism spectrum disorder
(ASD).
Methods: Motion coherence thresholds were assessed in a cohort of
40 ASD subjects and in 16 ASD siblings (aged 6–25 years) using
LumitrackTM software. Moving stimuli were either white dots on a
black background or black dots on a white background. ASD subject
data were compared with LumitrackTM motion coherence reference
limits, compiled from 97 typically developed individuals (aged
4–25 years). Light-adapted (LA) ERGs were recorded in the ASD
individuals and their siblings using the RETeval (LKC Technologies
Inc., Gaithersburg MD, USA). A Troland-based, random nine-step,
full-field flash series and ISCEV standard LA 3.0 cd s/m2 presented at
2/s on a 30 cd/m2 background was performed on both eyes. The aand
b-wave amplitudes and timing were measured for comparisons
between different groups.
Results: Motion coherence thresholds were elevated with mean
threshold 44% in both ASD (range 25–82%) and their sibling (range
25–85%) groups. However, 55% (22/40) of ASD subjects and 38%
(6/16) of their siblings had raised thresholds compared to the upper
reference limit of typically developed individuals which was 23%
(95th CI), with mean 9%. The mean ASD elevated threshold for black
dots on white background was 45% in both ASD and their siblings,
whereas those for white dots on black background were 42% and 44%
in ASD and siblings, respectively. The mean of the timing and
amplitudes of the a- and b-waves of LA3 ERGs did not significantly
differ between ASD and siblings with elevated motion coherence
thresholds. Mean LA3 ERG a-wave amplitudes were 7 lV (range
4–12 lV) for ASD subjects and 8 lV (range 3–12 lV) for their
siblings. Mean LA3 ERG b-wave amplitudes were 33 lV (range
16–50 lV) for ASD subjects and 35 lV for their siblings (range
27–51 lV). Mean LA3 ERG a-wave peak times were 12 ms for ASD
and 11 ms for their siblings and those of b-waves were 29 ms in ASD
compared with 28 ms in the sibling group.
Conclusions: The elevated motion coherence thresholds do not
appear to be associated with reported altered retinal signaling measured
by LA electroretinography.
| Original language | English |
|---|---|
| Pages | S6 |
| Number of pages | 1 |
| Publication status | Published - 10 Oct 2019 |
| Event | 57th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2019), Seoul, Korea, 7–10 October 2019 - South Korea, Seoul, Korea, Republic of Duration: 7 Oct 2019 → 10 Oct 2019 http://iscev2019.com/ |
Conference
| Conference | 57th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2019), Seoul, Korea, 7–10 October 2019 |
|---|---|
| Country/Territory | Korea, Republic of |
| City | Seoul |
| Period | 7/10/19 → 10/10/19 |
| Internet address |
Keywords
- motion coherence
- autism spectrum disorder
- electroretinography