Are motion coherence thresholds in individuals with autism spectrum disorder associated with retinal function?

Irene Lee, Dennis M Fritsch, Maximilian Kerz, Jane C Sowden, Paul A Constable, David H Skuse, Dorothy A Thompson

Research output: Contribution to conferencePoster

Abstract

Purpose: To investigate whether motion coherence thresholds are
associated with altered retinal signaling in autism spectrum disorder
(ASD).
Methods: Motion coherence thresholds were assessed in a cohort of
40 ASD subjects and in 16 ASD siblings (aged 6–25 years) using
LumitrackTM software. Moving stimuli were either white dots on a
black background or black dots on a white background. ASD subject
data were compared with LumitrackTM motion coherence reference
limits, compiled from 97 typically developed individuals (aged
4–25 years). Light-adapted (LA) ERGs were recorded in the ASD
individuals and their siblings using the RETeval (LKC Technologies
Inc., Gaithersburg MD, USA). A Troland-based, random nine-step,
full-field flash series and ISCEV standard LA 3.0 cd s/m2 presented at
2/s on a 30 cd/m2 background was performed on both eyes. The aand
b-wave amplitudes and timing were measured for comparisons
between different groups.
Results: Motion coherence thresholds were elevated with mean
threshold 44% in both ASD (range 25–82%) and their sibling (range
25–85%) groups. However, 55% (22/40) of ASD subjects and 38%
(6/16) of their siblings had raised thresholds compared to the upper
reference limit of typically developed individuals which was 23%
(95th CI), with mean 9%. The mean ASD elevated threshold for black
dots on white background was 45% in both ASD and their siblings,
whereas those for white dots on black background were 42% and 44%
in ASD and siblings, respectively. The mean of the timing and
amplitudes of the a- and b-waves of LA3 ERGs did not significantly
differ between ASD and siblings with elevated motion coherence
thresholds. Mean LA3 ERG a-wave amplitudes were 7 lV (range
4–12 lV) for ASD subjects and 8 lV (range 3–12 lV) for their
siblings. Mean LA3 ERG b-wave amplitudes were 33 lV (range
16–50 lV) for ASD subjects and 35 lV for their siblings (range
27–51 lV). Mean LA3 ERG a-wave peak times were 12 ms for ASD
and 11 ms for their siblings and those of b-waves were 29 ms in ASD
compared with 28 ms in the sibling group.
Conclusions: The elevated motion coherence thresholds do not
appear to be associated with reported altered retinal signaling measured
by LA electroretinography.
Original languageEnglish
PagesS6
Number of pages1
Publication statusPublished - 10 Oct 2019
Event57th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2019), Seoul, Korea, 7–10 October 2019 - South Korea, Seoul, Korea, Republic of
Duration: 7 Oct 201910 Oct 2019
http://iscev2019.com/

Conference

Conference57th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2019), Seoul, Korea, 7–10 October 2019
CountryKorea, Republic of
CitySeoul
Period7/10/1910/10/19
Internet address

Keywords

  • motion coherence
  • autism spectrum disorder
  • electroretinography

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