ARID proteins come in from the desert

Robert Daniel Kortschak, Philip W. Tucker, Robert B. Saint

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)


Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.
Original languageEnglish
Pages (from-to)294-299
Number of pages6
JournalTrends in Biochemical Sciences
Issue number6
Publication statusPublished - 1 Jun 2000


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