Ascending Aorta and Myocardial Mechanics in Patients with “Clinically Normal” Bicuspid Aortic Valve: Insights from Cardiovascular Magnetic Resonance Tissue-Tracking Imaging

Gaetano Nucifora, Jamie Miller, Carl Gillebert, Ranjit Shah, Rebecca Perry, Cherie Raven, Majo X. Joseph, Joseph B. Selvanayagam

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aortic valve dysfunction and aortic wall changes are well-known complications of bicuspid aortic valve (BAV) disease. The aim of the present study was to investigate whether a remodeling process of the left ventricle (LV) is present in patients with isolated BAV. Twenty-two consecutive patients (39 ± 15 years, 9 males) with clinically normal BAV and 18 age-and gender-matched control subjects (37 ± 10 years, 9 males) were included. Cardiovascular magnetic resonance (CMR) imaging was performed to evaluate LV function, aortic valve morphology, aortic orifice area, and ascending aorta (AA) dimensions. Tissue-tracking analysis was applied to assess LV systolic and diastolic myocardial mechanics in the longitudinal, circumferential, and radial direction and AA circumferential strain (CS). No significant difference was observed between BAV and controls regarding LV ejection fraction and LV mass index. Tissue-tracking analysis demonstrated that BAV patients had significantly impaired LV systolic and diastolic myocardial mechanics. BAV patients had also significantly lower AA CS compared with controls. At multivariate analysis, the presence of BAV was the only variable significantly and independently related to the impaired AA and LV systolic myocardial mechanics. In conclusion, LV myocardial deformation properties are impaired among BAV patients. The impairment of LV systolic mechanics observed in BAV patients appears to be related only to the congenital abnormality of the aortic valve itself.

Original languageEnglish
Pages (from-to)741-749
Number of pages9
JournalInternational Heart Journal
Volume59
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Aortic wall
  • Deformation
  • Left ventricle
  • Magnetic resonance imaging
  • Myocardium
  • Strain

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