Ascorbic acid, and not L-DOPA, protects against form-deprivation myopia in retinal degeneration mouse models

Erica Landis, Hanna Park, Ranjay Chakraborty, Curran Sidhu, P. Michael Iuvone, Machelle T. Pardue

Research output: Contribution to conferenceAbstractpeer-review

Abstract

Mouse models of retinal degeneration have shown increased susceptibility to form deprivation myopia, potentially due to decreased dopamine (DA) turnover (Park et al., 2013) or loss of dopaminergic amacrine cells (DACs; Ivanova et al., 2015). The purpose of this work is to test whether systemic injections of the DA precursor, L-3,4-dihydroxyphenylalanine (L-DOPA) will protect against form deprivation (FD) myopia in wild-type and retinal degeneration mice.
Original languageEnglish
Number of pages2
Publication statusPublished - Sep 2016
Externally publishedYes
EventARVO 2016 Annual Meeting - Seattle, United States
Duration: 1 May 20165 May 2016

Conference

ConferenceARVO 2016 Annual Meeting
Abbreviated titleARVO 2016
CountryUnited States
CitySeattle
Period1/05/165/05/16

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

Keywords

  • retinal degeneration
  • mice
  • myopia
  • decreased dopamine

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