Asperfloketals A and B, the first two ergostanes with rearranged A and D rings: From the Sponge-Associated Aspergillus flocculosus 16D-1

Fu Rong Jiao, Bin Bin Gu, Hong Rui Zhu, Yun Zhang, Ke Chun Liu, Wei Zhang, Hua Han, Shi Hai Xu, Hou Wen Lin

Research output: Contribution to journalArticlepeer-review

Abstract

Asperfloketals A (1) and B (2), two 1(10 → 6)-abeo-14,15-secosteroids featuring a novel trioxahexaheterocyclic ring system, were isolated from the sponge-associated fungus Aspergillus flocculosus 16D-1. Their structures were elucidated by extensive spectroscopic analysis and NMR chemical shifts calculations, supported by DP4+ probability analysis, and their absolute configurations were determined by ECD calculations and the modified Mosher's method. Asperfloketals A and B showed strong anti-inflammatory activity in the CuSO4-induced transgenic fluorescent zebrafish but displayed no cytotoxicity against HeLa, HepG2, and SW480 cell lines.

Original languageEnglish
Pages (from-to)10954-10961
Number of pages8
JournalJournal of Organic Chemistry
Volume86
Issue number16
DOIs
Publication statusPublished - 20 Aug 2021
Externally publishedYes

Fingerprint

Dive into the research topics of 'Asperfloketals A and B, the first two ergostanes with rearranged A and D rings: From the Sponge-Associated Aspergillus flocculosus 16D-1'. Together they form a unique fingerprint.

Cite this