Assessment and interpretation of sleep disordered breathing in cardiology: Clinical implications and perspectives

Dominik Linz, Mathias Baumert, Peter Catcheside, John Floras, Prashanthan Sanders, Patrick Levy, Martin Cowie, Ronald McEvoy, Doug McEvoy

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Sleep disordered breathing (SDB) is highly prevalent in patients with atrial fibrillation, heart failure and hypertension and is associated with increased risk of mortality, cardiovascular (CV) events and arrhythmias. Current assessment of the severity of SDB is mainly based on the apnea-hypopnea index (AHI) representing the number of hypopneas and apneas per hour of sleep. However, this event-based parameter alone may not sufficiently reflect the complex pathophysiological mechanisms underlying SDB potentially contributing to CV outcome risk. In this review article, we highlight important limitations and pitfalls of current assessment, quantification and interpretation of SDB-severity in patients with CV disease and will discuss pathophysiological considerations from preclinical and clinical mechanistic studies and possible clinical implications.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalInternational Journal of Cardiology
Volume271
DOIs
Publication statusPublished - 15 Nov 2018

Keywords

  • Arrhythmias
  • Atrial fibrillation
  • Heart failure
  • Hypoxia
  • Sleep apnea
  • Sleep disordered breathing

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