TY - JOUR
T1 - Assessment of a novel blinding device for nerve catheter studies
T2 - a randomised ex vivo study
AU - Badenoch, Adam
AU - Hijazi, Baha'a
AU - Scotland, Vanessa
AU - de Prinse, Louise
AU - Moffat, Leah
AU - Smith, Thomas
AU - Frances, Hayden
AU - Baker, Andrew
AU - Schwerdtfeger, Claire
AU - Crossman, Mason
AU - Herd, Jarryd
AU - Lee, Krystal
AU - Paull, Sam
AU - Kingston, Elise
AU - Mittinty, Murthy
PY - 2024/1
Y1 - 2024/1
N2 - Unblinded studies overestimate treatment effects compared with blinded studies. Therefore, blinding participants and outcome assessors is an important aspect of study design to minimise potential bias. Blinding is particularly important for studies involving subjective outcomes such as pain, satisfaction, or quality of recovery, which are commonly assessed outcomes in studies investigating the efficacy of regional anaesthesia techniques. However, blinding is particularly difficult to achieve in procedure-related research when compared with pharmaceutical research. Despite its importance as a scientific principle, the success or failure of blinding is frequently not assessed. Furthermore, when it is assessed, it has been consistently demonstrated that blinding is often not achieved in practice.
AB - Unblinded studies overestimate treatment effects compared with blinded studies. Therefore, blinding participants and outcome assessors is an important aspect of study design to minimise potential bias. Blinding is particularly important for studies involving subjective outcomes such as pain, satisfaction, or quality of recovery, which are commonly assessed outcomes in studies investigating the efficacy of regional anaesthesia techniques. However, blinding is particularly difficult to achieve in procedure-related research when compared with pharmaceutical research. Despite its importance as a scientific principle, the success or failure of blinding is frequently not assessed. Furthermore, when it is assessed, it has been consistently demonstrated that blinding is often not achieved in practice.
KW - double-blind
KW - nerve block
KW - placebo effect
KW - regional anaesthesia
KW - sham treatment
UR - http://www.scopus.com/inward/record.url?scp=85176922238&partnerID=8YFLogxK
U2 - 10.1016/j.bja.2023.10.005
DO - 10.1016/j.bja.2023.10.005
M3 - Letter
C2 - 37923582
AN - SCOPUS:85176922238
SN - 0007-0912
VL - 132
SP - 184
EP - 186
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 1
ER -