Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia

Tewodros Shibabaw; Gashaw Dessie; Meseret Derbew Molla; Muluken Fekadie Zerihun; Birhanu Ayelign

doi:10.1186/s13104-019-4742-x

Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia

Tewodros Shibabaw
, Gashaw Dessie
, Meseret Derbew Molla
, Muluken Fekadie Zerihun
, Birhanu Ayelign

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

3 Downloads (Pure)

Abstract

Objective: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. Results: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer's kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls.

Original language	English
Article number	707
Number of pages	5
Journal	BMC Research Notes
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/s13104-019-4742-x
Publication status	Published - 29 Oct 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alanine aminotransaminase
Aspartate aminotransaminase
Gamma-glutamyltransferase

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10.1186/s13104-019-4742-xLicence: CC BY

Published versionFinal published version, 778 KBLicence: CC BY

Cite this

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title = "Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia",

abstract = "Objective: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. Results: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer's kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls.",

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AU - Shibabaw, Tewodros

AU - Dessie, Gashaw

AU - Molla, Meseret Derbew

AU - Zerihun, Muluken Fekadie

AU - Ayelign, Birhanu

PY - 2019/10/29

Y1 - 2019/10/29

N2 - Objective: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. Results: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer's kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls.

AB - Objective: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. Results: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer's kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls.

KW - Alanine aminotransaminase

KW - Aspartate aminotransaminase

KW - Gamma-glutamyltransferase

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JO - BMC Research Notes

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ER -

Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia

Abstract

UN SDGs

Keywords

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