Assessment of the anti-inflammatory action of calcium dobesilate. Effect on macrophage attaching to subcutaneously implanted coverslips in guinea pigs

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Abstract

Calcium dobesilate (Doxium®) has been shown to significantly reduce the attachment of activated and quiescent macrophages to subcutaneously implanted coverslips in guinea pigs. Since the implanted coverslips represent an inflammatory stimulus and macrophages have a dominant role in inflammation it suggests that calcium dobesilate may have a pronounced anti-inflammatory action. It is speculated that calcium dobesilate may do this by reducing the number of circulating monocytes, by blocking the action of macrophage activating factors or more likely by stimulating a more rapid production of host macrophage deactivating factors such as Transforming Growth Factor (TGF) beta 1 and 2.

Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume40
Issue number6
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • anti-inflammatories
  • calcium dobesilate, pharmacology
  • Doxium®
  • macrophages

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