TY - JOUR
T1 - Assessment of the Construct Validity of the EQ-5D in Patients with Acute Cough/Lower Respiratory Tract Infections
AU - Oppong, Raymond
AU - Kaambwa, Billingsley
AU - Nuttall, Jacqui
AU - Hood, Kerenza
AU - Smith, Richard
AU - Coast, Joanna
PY - 2011/12
Y1 - 2011/12
N2 - Although EQ-5D has been used in the context of acute cough/lower respiratory tract infections (acute cough/LRTI), it has not been formally validated in this disease area. The primary aim of this study is to assess the construct validity of EQ-5D as a measure for economic evaluation in the context of acute cough/lower respiratory tract infections. Data were collected alongside an observational study of the management of patients with acute cough/LRTI in thirteen European countries. However, the analysis was limited to 349 patients from the UK. Hypotheses were specified a priori and tested in order to establish the construct validity of EQ-5D. Statistical methods used to test the a priori hypotheses included Wilcoxon signed rank sum test, Kruskal-Wallis test, Chi-square test and regression analysis. Most of the relationships that were tested were in line with the a priori hypotheses. The main results indicate that there was a negative relationship between symptom severity scores and EQ-5D, smoking was associated with worse EQ-5D scores and EQ-5D was able to discriminate between patients with headache, interference with normal activities and disturbed sleep. This study also showed that the EQ-5D is moderately responsive in patients with acute cough/LRTI, and is a suitable measure for use in economic evaluation studies of acute cough/LRTI
AB - Although EQ-5D has been used in the context of acute cough/lower respiratory tract infections (acute cough/LRTI), it has not been formally validated in this disease area. The primary aim of this study is to assess the construct validity of EQ-5D as a measure for economic evaluation in the context of acute cough/lower respiratory tract infections. Data were collected alongside an observational study of the management of patients with acute cough/LRTI in thirteen European countries. However, the analysis was limited to 349 patients from the UK. Hypotheses were specified a priori and tested in order to establish the construct validity of EQ-5D. Statistical methods used to test the a priori hypotheses included Wilcoxon signed rank sum test, Kruskal-Wallis test, Chi-square test and regression analysis. Most of the relationships that were tested were in line with the a priori hypotheses. The main results indicate that there was a negative relationship between symptom severity scores and EQ-5D, smoking was associated with worse EQ-5D scores and EQ-5D was able to discriminate between patients with headache, interference with normal activities and disturbed sleep. This study also showed that the EQ-5D is moderately responsive in patients with acute cough/LRTI, and is a suitable measure for use in economic evaluation studies of acute cough/LRTI
KW - Cough
KW - EQ-5D
KW - Lower respiratory tract infections
KW - Validity
UR - http://www.scopus.com/inward/record.url?scp=80355132317&partnerID=8YFLogxK
U2 - 10.1007/s11482-011-9137-7
DO - 10.1007/s11482-011-9137-7
M3 - Article
VL - 6
SP - 411
EP - 423
JO - Applied Research in Quality of Life
JF - Applied Research in Quality of Life
SN - 1871-2584
IS - 4
ER -