Association between alcohol consumption and diabetic retinopathy and visual acuity - The AdRem Study

Cheetin Lee, Ronald Stolk, Amanda Adler, Anushka Patel, John Chalmers, Bruce Neal, Neil Poulter, Stephen Harrap, Mark Woodward, Michel Marre, Diederick Grobbee, Joline Beulens

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Aims We investigated the association between alcohol consumption and diabetic retinopathy and deterioration of visual acuity in individuals with Type 2 diabetes. Methods We conducted a cohort analysis of 1239 participants with Type 2 diabetes aged 55-81 years enrolled in the AdRem study, a sub-study of the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial. Current and past consumption of wine, spirits and beer was measured by self-report. Moderate and heavy alcohol consumption was defined as 1-14 and > 14 drinks/week, respectively. Diabetic retinopathy, measured by mydriatic stereoscopic seven-field retinal photography, was defined by a 2-step progression in the Early Treatment of Diabetic Retinopathy Study (ETDRS) score or the presence of any retinal vascular lesions. Deterioration of visual acuity was defined by a decrease of two lines in best vision in either eye, measured corrected, or through a pinhole using a Snellen chart. Results In a mean follow-up of 5.5 years, we identified 182 participants with a 2-step progression in the ETDRS score, 640 participants with the presence of any retinal vascular lesions and 693 participants with a deterioration of visual acuity. Current moderate consumption of alcohol, compared with no current consumption, was not associated with presence or progression of diabetic retinopathy; however, it was associated with higher risk of deterioration of visual acuity (multivariable-adjusted OR 1.83; 95% CI 1.34-2.48; P < 0.001). Conclusions Alcohol consumption is associated with increased risk of deterioration of visual acuity, but not with retinopathy in individuals with Type 2 diabetes.

    Original languageEnglish
    Pages (from-to)1130-1137
    Number of pages8
    JournalDiabetic Medicine
    Volume27
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

    Keywords

    • alcohol consumption
    • diabetic retinopathy
    • visual acuity

    Fingerprint Dive into the research topics of 'Association between alcohol consumption and diabetic retinopathy and visual acuity - The AdRem Study'. Together they form a unique fingerprint.

  • Cite this

    Lee, C., Stolk, R., Adler, A., Patel, A., Chalmers, J., Neal, B., Poulter, N., Harrap, S., Woodward, M., Marre, M., Grobbee, D., & Beulens, J. (2010). Association between alcohol consumption and diabetic retinopathy and visual acuity - The AdRem Study. Diabetic Medicine, 27(10), 1130-1137. https://doi.org/10.1111/j.1464-5491.2010.03080.x