TY - JOUR
T1 - Association between metabolic obesity phenotypes and risk of colorectal neoplasia in a south Australian surveillance colonoscopy population
AU - Molla, Meseret Derbew
AU - Symonds, Erin L.
AU - Winter, Jean M.
AU - Cock, Charles
AU - Wassie, Molla M.
PY - 2026/1
Y1 - 2026/1
N2 - Objective: To assess association between metabolic obesity phenotypes and risk of colorectal neoplasia in a South Australian surveillance colonoscopy population. Methods: A retrospective cohort study in individuals undergoing surveillance colonoscopy between February 24, 2021, to May 25, 2024, was conducted. The four groups based on obesity and metabolic health status were: metabolically healthy non-obesity (MHNO) or obesity (MHO) and metabolically unhealthy non-obesity (MUNO) or obesity (MUO). Metabolically unhealthy status based on the presence of type 2 diabetes, hypertension, or dyslipidemia) and colonoscopy outcomes were collected from clinical databases. Multivariable logistic regression was applied in the overall as well as subgroup analysis by sex of participants. Results: Both MHO (adjusted odds ratio (AOR) = 1.36, 95 % CI 1.00, 1.85) and MUO (AOR = 1.39, 95 % CI 1.11,1.76) were positively associated with the risk of conventional adenoma but not with serrated polyps as compared to non-neoplastic groups. An increased risk of advanced conventional adenoma was observed in individuals with MHO (AOR = 1.38, 95 % CI 1.04, 1.83) and MUO (AOR = 1.27, 95 % CI 1.03,1.58). This risk for advanced conventional adenomas was significant in male participants, but not in females. Conclusions: Obesity, independent of other metabolic diseases, was associated with a higher risk of conventional adenoma, particularly in males.
AB - Objective: To assess association between metabolic obesity phenotypes and risk of colorectal neoplasia in a South Australian surveillance colonoscopy population. Methods: A retrospective cohort study in individuals undergoing surveillance colonoscopy between February 24, 2021, to May 25, 2024, was conducted. The four groups based on obesity and metabolic health status were: metabolically healthy non-obesity (MHNO) or obesity (MHO) and metabolically unhealthy non-obesity (MUNO) or obesity (MUO). Metabolically unhealthy status based on the presence of type 2 diabetes, hypertension, or dyslipidemia) and colonoscopy outcomes were collected from clinical databases. Multivariable logistic regression was applied in the overall as well as subgroup analysis by sex of participants. Results: Both MHO (adjusted odds ratio (AOR) = 1.36, 95 % CI 1.00, 1.85) and MUO (AOR = 1.39, 95 % CI 1.11,1.76) were positively associated with the risk of conventional adenoma but not with serrated polyps as compared to non-neoplastic groups. An increased risk of advanced conventional adenoma was observed in individuals with MHO (AOR = 1.38, 95 % CI 1.04, 1.83) and MUO (AOR = 1.27, 95 % CI 1.03,1.58). This risk for advanced conventional adenomas was significant in male participants, but not in females. Conclusions: Obesity, independent of other metabolic diseases, was associated with a higher risk of conventional adenoma, particularly in males.
KW - Colorectal neoplasms
KW - Conventional adenoma
KW - Metabolically healthy obesity
KW - Metabolically unhealthy obesity
KW - Serrated polyps
KW - Surveillance colonoscopy
UR - http://www.scopus.com/inward/record.url?scp=105026767675&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/2009050
U2 - 10.1016/j.pmedr.2025.103360
DO - 10.1016/j.pmedr.2025.103360
M3 - Article
AN - SCOPUS:105026767675
SN - 2211-3355
VL - 61
JO - Preventive Medicine Reports
JF - Preventive Medicine Reports
M1 - 103360
ER -