Association between multimorbidity and undiagnosed obstructive sleep apnea severity and their impact on quality of life in men over 40 years old

G Ruel, S. A. Martin, J Levesque, G Wittert, R. J. Adams, S. L. Appleton, Z. Shi, A. W. Taylor

Research output: Contribution to journalArticle

4 Citations (Scopus)
3 Downloads (Pure)

Abstract

Background.
Multimorbidity is common but little is known about its relationship with obstructive sleep apnea (OSA).
Methods.
Men Androgen Inflammation Lifestyle Environment and Stress Study participants underwent polysomnography. Chronic diseases (CDs) were determined by biomedical measurement (diabetes, dyslipidaemia, hypertension, obesity), or self-report (depression, asthma, cardiovascular disease, arthritis). Associations between CD count, multimorbidity, apnea-hyponea index (AHI) and OSA severity and quality-of-life (QoL; mental & physical component scores), were determined using multinomial regression analyses, after adjustment for age.
Results.
Of the 743 men participating in the study, overall 58% had multimorbidity (2+ CDs), and 52% had OSA (11% severe). About 70% of those with multimorbidity had undiagnosed OSA. Multimorbidity was associated with AHI and undiagnosed OSA. Elevated CD count was associated with higher AHI value and increased OSA severity.
Conclusion.
We demonstrate an independent association between the presence of OSA and multimorbidity in this representative sample of community-based men. This effect was strongest in men with moderate to severe OSA and three or more CDs, and appeared to produce a greater reduction in QoL when both conditions were present together.
Original languageEnglish
Article numbere10
Pages (from-to)e10
Number of pages9
JournalGlobal Health, Epidemiology and Genomics
Volume3
DOIs
Publication statusPublished - 4 Jun 2018
Externally publishedYes

Bibliographical note

Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • obstructive sleep apnea
  • Multimorbidity
  • Men Androgen Inflammation Lifestyle Environment and Stress Study
  • Apnea-hypopnea index
  • chronic disease
  • comorbidity
  • quality of life

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