Association between relative peripheral refraction and corresponding electro-retinal signals

Satish Kumar Gupta, Ranjay Chakraborty, Pavan Kumar Verkicharla

Research output: Contribution to journalArticlepeer-review


Purpose: Considering the potential role of the peripheral retina in refractive development and given that peripheral refraction varies significantly with increasing eccentricity from the fovea, we investigated the association between relative peripheral refraction (RPR) and corresponding relative peripheral multifocal electroretinogram (mfERG) responses (electro-retinal signals) from the central to the peripheral retina in young adults. 

Methods: Central and peripheral refraction using an open-field autorefractor and mfERG responses using an electrophysiology stimulator were recorded from the right eyes of 17 non-myopes and 24 myopes aged 20–27 years. The relative mfERG N1, P1 and N2 components (amplitude density and implicit time) of a mfERG waveform were compared with the corresponding RPR measurements at the best-matched eccentricities along the principal meridians, that is at the fovea (0°), horizontal (±5°, ±10° and ± 25°) and vertical meridians (±10° and ± 15°). 

Results: The mean absolute mfERG N1, P1 and N2 amplitude densities (nV/deg 2) were maximum at the fovea in both non-myopes (N1: 57.29 ± 14.70 nV/deg 2, P1: 106.29 ± 24.46 nV/deg 2, N2: 116.41 ± 27.96 nV/deg 2) and myopes (N1: 56.25 ± 15.79 nV/deg 2, P1: 100.79 ± 30.81 nV/deg 2, N2: 105.75 ± 37.91 nV/deg 2), which significantly reduced with increasing retinal eccentricity (p < 0.01). No significant association was reported between the RPR and corresponding relative mfERG amplitudes at each retinal eccentricity (overall Pearson's correlation, r = −0.25 to 0.26, p ≥ 0.09). In addition, the presence of relative peripheral myopia or hyperopia at extreme peripheral retinal eccentricities did not differentially influence the corresponding relative peripheral mfERG amplitudes (p ≥ 0.24). 

Conclusions: Relative peripheral mfERG signals are not associated with corresponding RPR in young adults. It is plausible that the electro-retinal signals may respond to the presence of absolute hyperopia (and not relative peripheral hyperopia), which requires further investigation.

Original languageEnglish
Pages (from-to)482-493
Number of pages12
JournalOphthalmic and Physiological Optics
Issue number3
Early online date7 Mar 2023
Publication statusPublished - May 2023


  • electrophysiology
  • electro-retinal signals
  • multifocal electroretinogram
  • myopia
  • peripheral refraction
  • retinal defocus


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