TY - JOUR
T1 - Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation
T2 - Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach
AU - Raman, Betty
AU - Tunnicliffe, Elizabeth M.
AU - Chan, Kenneth
AU - Ariga, Rina
AU - Hundertmark, Moritz
AU - Ohuma, Eric O.
AU - Sivalokanathan, Sanjay
AU - Tan, Yi Jie Gifford
AU - Mahmod, Masliza
AU - Hess, Aaron T.
AU - Karamitsos, Theodoros D.
AU - Selvanayagam, Joseph
AU - Jerosch-Herold, Michael
AU - Watkins, Hugh
AU - Neubauer, Stefan
PY - 2021/11/16
Y1 - 2021/11/16
N2 - Elucidating the effects of sarcomeric variants on the hypertrophic cardiomyopathy (HCM) pheno-type is a major research priority with potential to accelerate disease-specific therapeutic development. We and others, have previously described the adverse impact of sarcomeric (Sarc+) mutations on myocardial oxygenation among patients with HCM after vasodilator stress using a standard oxygen-sensitive cardiovascular magnetic resonance (CMR) approach. Although widely used, vasodilator stress oxygenation measured by T2-prepared steady-state free precession blood oxygen level–dependent imaging (T2-prep SSFP BOLD) suffers from low precision attributable to coil sensitivity (B1−) variations and heart rate (HR) changes. B1 variation matters when breath-hold positions differ during vasodilator provocation.
AB - Elucidating the effects of sarcomeric variants on the hypertrophic cardiomyopathy (HCM) pheno-type is a major research priority with potential to accelerate disease-specific therapeutic development. We and others, have previously described the adverse impact of sarcomeric (Sarc+) mutations on myocardial oxygenation among patients with HCM after vasodilator stress using a standard oxygen-sensitive cardiovascular magnetic resonance (CMR) approach. Although widely used, vasodilator stress oxygenation measured by T2-prepared steady-state free precession blood oxygen level–dependent imaging (T2-prep SSFP BOLD) suffers from low precision attributable to coil sensitivity (B1−) variations and heart rate (HR) changes. B1 variation matters when breath-hold positions differ during vasodilator provocation.
KW - BOLD protocol
KW - cardiomyopathy, hypertrophic
KW - magnetic resonance imaging
KW - perfusion
KW - sarcomeric HCM
UR - http://www.scopus.com/inward/record.url?scp=85121960617&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.121.054015
DO - 10.1161/CIRCULATIONAHA.121.054015
M3 - Letter
C2 - 34780254
AN - SCOPUS:85121960617
SN - 0009-7322
VL - 144
SP - 1656
EP - 1658
JO - Circulation
JF - Circulation
IS - 20
ER -