Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach

Betty Raman; Elizabeth M. Tunnicliffe; Kenneth Chan; Rina Ariga; Moritz Hundertmark; Eric O. Ohuma; Sanjay Sivalokanathan; Yi Jie Gifford Tan; Masliza Mahmod; Aaron T. Hess; Theodoros D. Karamitsos; Joseph Selvanayagam; Michael Jerosch-Herold; Hugh Watkins; Stefan Neubauer

doi:10.1161/CIRCULATIONAHA.121.054015

Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach

Betty Raman, Elizabeth M. Tunnicliffe, Kenneth Chan, Rina Ariga, Moritz Hundertmark, Eric O. Ohuma, Sanjay Sivalokanathan, Yi Jie Gifford Tan, Masliza Mahmod, Aaron T. Hess, Theodoros D. Karamitsos, Joseph Selvanayagam, Michael Jerosch-Herold, Hugh Watkins, Stefan Neubauer

College of Medicine and Public Health

Research output: Contribution to journal › Letter › peer-review

10 Citations (Scopus)

Abstract

Elucidating the effects of sarcomeric variants on the hypertrophic cardiomyopathy (HCM) pheno-type is a major research priority with potential to accelerate disease-specific therapeutic development. We and others, have previously described the adverse impact of sarcomeric (Sarc+) mutations on myocardial oxygenation among patients with HCM after vasodilator stress using a standard oxygen-sensitive cardiovascular magnetic resonance (CMR) approach. Although widely used, vasodilator stress oxygenation measured by T2-prepared steady-state free precession blood oxygen level–dependent imaging (T2-prep SSFP BOLD) suffers from low precision attributable to coil sensitivity (B1−) variations and heart rate (HR) changes. B1 variation matters when breath-hold positions differ during vasodilator provocation.

Original language	English
Pages (from-to)	1656-1658
Number of pages	3
Journal	Circulation
Volume	144
Issue number	20
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.121.054015
Publication status	Published - 16 Nov 2021

Keywords

BOLD protocol
cardiomyopathy, hypertrophic
magnetic resonance imaging
perfusion
sarcomeric HCM

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10.1161/CIRCULATIONAHA.121.054015Licence: In Copyright

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Raman, B., Tunnicliffe, E. M., Chan, K., Ariga, R., Hundertmark, M., Ohuma, E. O., Sivalokanathan, S., Tan, Y. J. G., Mahmod, M., Hess, A. T., Karamitsos, T. D., Selvanayagam, J., Jerosch-Herold, M., Watkins, H., & Neubauer, S. (2021). Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach. Circulation, 144(20), 1656-1658. https://doi.org/10.1161/CIRCULATIONAHA.121.054015

@article{0da0b65ec5c94d9092a9eb55e4fe04aa,

title = "Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach",

abstract = "Elucidating the effects of sarcomeric variants on the hypertrophic cardiomyopathy (HCM) pheno-type is a major research priority with potential to accelerate disease-specific therapeutic development. We and others, have previously described the adverse impact of sarcomeric (Sarc+) mutations on myocardial oxygenation among patients with HCM after vasodilator stress using a standard oxygen-sensitive cardiovascular magnetic resonance (CMR) approach. Although widely used, vasodilator stress oxygenation measured by T2-prepared steady-state free precession blood oxygen level–dependent imaging (T2-prep SSFP BOLD) suffers from low precision attributable to coil sensitivity (B1−) variations and heart rate (HR) changes. B1 variation matters when breath-hold positions differ during vasodilator provocation.",

keywords = "BOLD protocol, cardiomyopathy, hypertrophic, magnetic resonance imaging, perfusion, sarcomeric HCM",

author = "Betty Raman and Tunnicliffe, {Elizabeth M.} and Kenneth Chan and Rina Ariga and Moritz Hundertmark and Ohuma, {Eric O.} and Sanjay Sivalokanathan and Tan, {Yi Jie Gifford} and Masliza Mahmod and Hess, {Aaron T.} and Karamitsos, {Theodoros D.} and Joseph Selvanayagam and Michael Jerosch-Herold and Hugh Watkins and Stefan Neubauer",

year = "2021",

month = nov,

day = "16",

doi = "10.1161/CIRCULATIONAHA.121.054015",

language = "English",

volume = "144",

pages = "1656--1658",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

number = "20",

}

Raman, B, Tunnicliffe, EM, Chan, K, Ariga, R, Hundertmark, M, Ohuma, EO, Sivalokanathan, S, Tan, YJG, Mahmod, M, Hess, AT, Karamitsos, TD, Selvanayagam, J, Jerosch-Herold, M, Watkins, H & Neubauer, S 2021, 'Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach', Circulation, vol. 144, no. 20, pp. 1656-1658. https://doi.org/10.1161/CIRCULATIONAHA.121.054015

Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach. / Raman, Betty; Tunnicliffe, Elizabeth M.; Chan, Kenneth et al.
In: Circulation, Vol. 144, No. 20, 16.11.2021, p. 1656-1658.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation

T2 - Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach

AU - Raman, Betty

AU - Tunnicliffe, Elizabeth M.

AU - Chan, Kenneth

AU - Ariga, Rina

AU - Hundertmark, Moritz

AU - Ohuma, Eric O.

AU - Sivalokanathan, Sanjay

AU - Tan, Yi Jie Gifford

AU - Mahmod, Masliza

AU - Hess, Aaron T.

AU - Karamitsos, Theodoros D.

AU - Selvanayagam, Joseph

AU - Jerosch-Herold, Michael

AU - Watkins, Hugh

AU - Neubauer, Stefan

PY - 2021/11/16

Y1 - 2021/11/16

N2 - Elucidating the effects of sarcomeric variants on the hypertrophic cardiomyopathy (HCM) pheno-type is a major research priority with potential to accelerate disease-specific therapeutic development. We and others, have previously described the adverse impact of sarcomeric (Sarc+) mutations on myocardial oxygenation among patients with HCM after vasodilator stress using a standard oxygen-sensitive cardiovascular magnetic resonance (CMR) approach. Although widely used, vasodilator stress oxygenation measured by T2-prepared steady-state free precession blood oxygen level–dependent imaging (T2-prep SSFP BOLD) suffers from low precision attributable to coil sensitivity (B1−) variations and heart rate (HR) changes. B1 variation matters when breath-hold positions differ during vasodilator provocation.

AB - Elucidating the effects of sarcomeric variants on the hypertrophic cardiomyopathy (HCM) pheno-type is a major research priority with potential to accelerate disease-specific therapeutic development. We and others, have previously described the adverse impact of sarcomeric (Sarc+) mutations on myocardial oxygenation among patients with HCM after vasodilator stress using a standard oxygen-sensitive cardiovascular magnetic resonance (CMR) approach. Although widely used, vasodilator stress oxygenation measured by T2-prepared steady-state free precession blood oxygen level–dependent imaging (T2-prep SSFP BOLD) suffers from low precision attributable to coil sensitivity (B1−) variations and heart rate (HR) changes. B1 variation matters when breath-hold positions differ during vasodilator provocation.

KW - BOLD protocol

KW - cardiomyopathy, hypertrophic

KW - magnetic resonance imaging

KW - perfusion

KW - sarcomeric HCM

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U2 - 10.1161/CIRCULATIONAHA.121.054015

DO - 10.1161/CIRCULATIONAHA.121.054015

M3 - Letter

C2 - 34780254

AN - SCOPUS:85121960617

SN - 0009-7322

VL - 144

SP - 1656

EP - 1658

JO - Circulation

JF - Circulation

IS - 20

ER -

Association between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights from a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach

Abstract

Keywords

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