TY - JOUR
T1 - Association Between Sleep Microstructure and Incident Hypertension in a Population-Based Sample
T2 - The HypnoLaus Study
AU - Berger, Mathieu
AU - Vakulin, Andrew
AU - Hirotsu, Camila
AU - Marchi, Nicola Andrea
AU - Solelhac, Geoffroy
AU - Bayon, Virginie
AU - Siclari, Francesca
AU - Haba-Rubio, José
AU - Vaucher, Julien
AU - Vollenweider, Peter
AU - Marques-Vidal, Pedro
AU - Lechat, Bastien
AU - Catcheside, Peter G.
AU - Eckert, Danny J.
AU - Adams, Robert J.
AU - Appleton, Sarah
AU - Heinzer, Raphael
PY - 2022/7/19
Y1 - 2022/7/19
N2 - BACKGROUND: Poor sleep quality is associated with increased incident hypertension. However, few studies have investigated the impact of objective sleep structure parameters on hypertension. This study investigated the association between sleep macrostructural and microstructural parameters and incident hypertension in a middle-to older-aged sample. METHODS AND RESULTS: Participants from the HypnoLaus population-based cohort without hypertension at baseline were included. Participants had at-home polysomnography at baseline, allowing assessment of sleep macrostructure (nonrapid eye movement sleep stages 1, 2, and 3; rapid eye movement sleep stages; and total sleep time) and microstructure including power spectral density of electroencephalogram in nonrapid eye movement sleep and spindles characteristics (density, duration, frequency, amplitude) in nonrapid eye movement sleep stage 2. Associations between sleep macrostructure and microstructure parameters at baseline and incident clinical hypertension over a mean follow-up of 5.2 years were assessed with multiple-adjusted logistic regression. A total of 1172 participants (42% men; age 55±10 years) were included. Of these, 198 (17%) developed hypertension. After adjustment for confounders, no sleep macrostructure features were associated with incident hypertension. However, low absolute delta and sigma power were significantly associated with incident hypertension where participants in the lowest quartile of delta and sigma had a 1.69-fold (95% CI, 1.00– 2.89) and 1.72-fold (95% CI, 1.05– 2.82) increased risk of incident hypertension, respectively, versus those in the highest quartile. Lower spindle density (odds ratio, 0.87; 95% CI, 0.76– 0.99) and amplitude (odds ratio, 0.98; 95% CI, 0.95–1.00) were also associated with higher incident hypertension. CONCLUSIONS: Sleep microstructure is associated with incident hypertension. Slow-wave activity and sleep spindles, 2 hall-marks of objective sleep continuity and quality, were inversely and consistently associated with incident hypertension. This supports the protective role of sleep continuity in the development of hypertension.
AB - BACKGROUND: Poor sleep quality is associated with increased incident hypertension. However, few studies have investigated the impact of objective sleep structure parameters on hypertension. This study investigated the association between sleep macrostructural and microstructural parameters and incident hypertension in a middle-to older-aged sample. METHODS AND RESULTS: Participants from the HypnoLaus population-based cohort without hypertension at baseline were included. Participants had at-home polysomnography at baseline, allowing assessment of sleep macrostructure (nonrapid eye movement sleep stages 1, 2, and 3; rapid eye movement sleep stages; and total sleep time) and microstructure including power spectral density of electroencephalogram in nonrapid eye movement sleep and spindles characteristics (density, duration, frequency, amplitude) in nonrapid eye movement sleep stage 2. Associations between sleep macrostructure and microstructure parameters at baseline and incident clinical hypertension over a mean follow-up of 5.2 years were assessed with multiple-adjusted logistic regression. A total of 1172 participants (42% men; age 55±10 years) were included. Of these, 198 (17%) developed hypertension. After adjustment for confounders, no sleep macrostructure features were associated with incident hypertension. However, low absolute delta and sigma power were significantly associated with incident hypertension where participants in the lowest quartile of delta and sigma had a 1.69-fold (95% CI, 1.00– 2.89) and 1.72-fold (95% CI, 1.05– 2.82) increased risk of incident hypertension, respectively, versus those in the highest quartile. Lower spindle density (odds ratio, 0.87; 95% CI, 0.76– 0.99) and amplitude (odds ratio, 0.98; 95% CI, 0.95–1.00) were also associated with higher incident hypertension. CONCLUSIONS: Sleep microstructure is associated with incident hypertension. Slow-wave activity and sleep spindles, 2 hall-marks of objective sleep continuity and quality, were inversely and consistently associated with incident hypertension. This supports the protective role of sleep continuity in the development of hypertension.
KW - delta power
KW - hypertension
KW - power spectral density
KW - sleep architecture
KW - sleep structure
KW - slow wave sleep
KW - spindle
UR - http://www.scopus.com/inward/record.url?scp=85134706684&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1116942
UR - http://purl.org/au-research/grants/NHMRC/1196261
U2 - 10.1161/JAHA.121.025828
DO - 10.1161/JAHA.121.025828
M3 - Article
C2 - 35861817
AN - SCOPUS:85134706684
SN - 2047-9980
VL - 11
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 14
M1 - e025828
ER -