TY - JOUR
T1 - Association of CD247 Polymorphisms with Rheumatoid Arthritis
T2 - A Replication Study and a Meta-Analysis
AU - Teruel, María
AU - McKinney, Cushla
AU - Balsa, Alejandro
AU - Pascual-Salcedo, Dora
AU - Rodriguez-Rodriguez, Luis
AU - Ortiz, Ana M.
AU - Gómez-Vaquero, Carmen
AU - González-Gay, Miguel A.
AU - Smith, Malcolm
AU - Witte, Torsten
AU - Merriman, Tony
AU - Lie, Benedicte A.
AU - Martin, Javier
PY - 2013/7/5
Y1 - 2013/7/5
N2 - Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10-10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.
AB - Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10-10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.
UR - http://www.scopus.com/inward/record.url?scp=84879832865&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0068295
DO - 10.1371/journal.pone.0068295
M3 - Review article
C2 - 23861880
AN - SCOPUS:84879832865
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 7
M1 - e68295
ER -