Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies

Alexandra Schosser, D. Gaysina, Sarah Cohen-Woods, P. C. Chow, L. Martucci, N. Craddock, Anne Farmer, A. Korszun, C. Gunasinghe, J Gray, F Tozzi, Julia Perry, Pierandrea Muglia, Michael Owen, Ian Craig, Peter McGuffin

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene.

    Original languageEnglish
    Pages (from-to)844-849
    Number of pages6
    JournalMOLECULAR PSYCHIATRY
    Volume15
    Issue number8
    DOIs
    Publication statusPublished - Aug 2010

    Keywords

    • association
    • bipolar disorder
    • depression
    • psychosis

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