Association of expired nitric oxide with occupational particulate exposure

Jee Young Kim; Matthew P. Wand; Russ Hauser; Sutapa Mukherjee; Robert F. Herrick; David C. Christiani

doi:10.1289/ehp.5880

Association of expired nitric oxide with occupational particulate exposure

Jee Young Kim, Matthew P. Wand, Russ Hauser, Sutapa Mukherjee, Robert F. Herrick, David C. Christiani

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (F_ENO) and exposure to particulate matter with an aerodynamic mass median diameter of ≤ 2.5 μm (PM_2.5) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20 or 2000 (n = 14). The Wilcoxon median baseline F_ENO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM_2.5 8-hr time-weighted average was 0.56 mg/m³ (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m³ (95% CI: 0.65, 1.07) in 2000. F_ENO levels during the work week were significantly lower than baseline F_ENO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed F_ENO and the previous workday's PM_2.5 concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m³ incremental increase in PM_2.5 exposure, log F_ENO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM_2.5 exposure and F_ENO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in F_ENO in a survey of workers with limited respirator usage.

Original language	English
Pages (from-to)	676-680
Number of pages	5
Journal	Environmental Health Perspectives
Volume	111
Issue number	5
DOIs	https://doi.org/10.1289/ehp.5880
Publication status	Published - 1 May 2003
Externally published	Yes

Bibliographical note

EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

Keywords

Air pollutants
Epidemiology
Nitric oxide
Occupational
Particulate matter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1289/ehp.5880Licence: In Copyright

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title = "Association of expired nitric oxide with occupational particulate exposure",

abstract = "Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to particulate matter with an aerodynamic mass median diameter of ≤ 2.5 μm (PM2.5) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20 or 2000 (n = 14). The Wilcoxon median baseline FENO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM2.5 8-hr time-weighted average was 0.56 mg/m3 (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m3 (95% CI: 0.65, 1.07) in 2000. FENO levels during the work week were significantly lower than baseline FENO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed FENO and the previous workday's PM2.5 concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m3 incremental increase in PM2.5 exposure, log FENO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM2.5 exposure and FENO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in FENO in a survey of workers with limited respirator usage.",

keywords = "Air pollutants, Epidemiology, Nitric oxide, Occupational, Particulate matter",

author = "Kim, {Jee Young} and Wand, {Matthew P.} and Russ Hauser and Sutapa Mukherjee and Herrick, {Robert F.} and Christiani, {David C.}",

note = " EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. ",

year = "2003",

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doi = "10.1289/ehp.5880",

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pages = "676--680",

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AU - Kim, Jee Young

AU - Wand, Matthew P.

AU - Hauser, Russ

AU - Mukherjee, Sutapa

AU - Herrick, Robert F.

AU - Christiani, David C.

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N2 - Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to particulate matter with an aerodynamic mass median diameter of ≤ 2.5 μm (PM2.5) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20 or 2000 (n = 14). The Wilcoxon median baseline FENO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM2.5 8-hr time-weighted average was 0.56 mg/m3 (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m3 (95% CI: 0.65, 1.07) in 2000. FENO levels during the work week were significantly lower than baseline FENO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed FENO and the previous workday's PM2.5 concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m3 incremental increase in PM2.5 exposure, log FENO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM2.5 exposure and FENO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in FENO in a survey of workers with limited respirator usage.

AB - Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to particulate matter with an aerodynamic mass median diameter of ≤ 2.5 μm (PM2.5) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20 or 2000 (n = 14). The Wilcoxon median baseline FENO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM2.5 8-hr time-weighted average was 0.56 mg/m3 (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m3 (95% CI: 0.65, 1.07) in 2000. FENO levels during the work week were significantly lower than baseline FENO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed FENO and the previous workday's PM2.5 concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m3 incremental increase in PM2.5 exposure, log FENO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM2.5 exposure and FENO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in FENO in a survey of workers with limited respirator usage.

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KW - Epidemiology

KW - Nitric oxide

KW - Occupational

KW - Particulate matter

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DO - 10.1289/ehp.5880

M3 - Article

C2 - 12727593

AN - SCOPUS:0037768663

SN - 0091-6765

VL - 111

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EP - 680

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 5

ER -

Association of expired nitric oxide with occupational particulate exposure

Abstract

Bibliographical note

Keywords

UN SDGs

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